SML1314
SAG 二盐酸盐
≥98% (HPLC), lyophilized solid, smoothened (Smo) agonist
别名:
3-氯-N-[反式-4-（甲氨基）环己基]-N- [[3-（4-吡啶）苯基] 甲基]-苯并 [b] 噻吩-2-甲酰胺 二盐酸盐, Smoothened 激动剂
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关于此项目
经验公式（希尔记法）:
C28H28ClN3OS · 2HCl
化学文摘社编号:
分子量:
562.98
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
产品名称
SAG 二盐酸盐, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
lyophilized solid
storage condition
desiccated
color
white to beige
solubility
H2O: 20 mg/mL, clear
storage temp.
−20°C
SMILES string
O=C(C1=C(Cl)C2=C(C=CC=C2)S1)N([C@@]3([H])CC[C@@](NC)([H])CC3)CC4=CC(C5=CC=NC=C5)=CC=C4
InChI
1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3/t22-,23-
InChI key
VFSUUTYAEQOIMW-YHBQERECSA-N
相关类别
Application
Smoothened激动剂(SAG)二盐酸盐作为音猬因子(sonic hedgehog, SHH)通路激动剂已用于：
- 研究其对小鼠海马体细胞的影响
- 研究其对斑马鱼胚胎线粒体网络的影响
- 研究其对鼠胚胎成纤维细胞的影响
Biochem/physiol Actions
SAG 是一种强效且具有细胞渗透性的 smoothened (Smo) 激动剂。
SAG 是一种强效且具有细胞渗透性的 smoothened (Smo) 激动剂，可激活 Hedgehog 途径，抵消环巴胺对 Smo 的抑制。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 4
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Shirin Farheen et al.
Journal of biochemical and molecular toxicology, 37(2), e23241-e23241 (2022-10-08)
Glioma is a major brain tumor, and the associated mortality rate is very high. Contemporary therapies provide a chance of survival for 9-12 months. Therefore, a novel approach is essential to improve the survival rate. Sonic hedgehog (Shh) cell signaling
Lina Zhu et al.
PeerJ, 10, e13381-e13381 (2022-05-10)
Smoothened (SMO) protein is a member of the G protein-coupled receptor (GPCR) family that is involved in the Hedgehog (Hh) signaling pathway. It is a putative target for treating various cancers, including medulloblastoma and basal cell carcinoma (BCC). Characterizing membrane
Friederike Hantel et al.
Journal of cell science, 135(9) (2022-05-12)
Cilia are evolutionarily conserved organelles that orchestrate a variety of signal transduction pathways, such as sonic hedgehog (SHH) signaling, during embryonic development. Our recent studies have shown that loss of GID ubiquitin ligase function results in aberrant AMP-activated protein kinase
Maike Marczenke et al.
Development (Cambridge, England), 148(21) (2021-10-27)
Growth arrest-specific 1 (GAS1) acts as a co-receptor to patched 1, promoting sonic hedgehog (SHH) signaling in the developing nervous system. GAS1 mutations in humans and animal models result in forebrain and craniofacial malformations, defects ascribed to a function for
Michaela Prochazkova et al.
Development (Cambridge, England), 144(12), 2212-2221 (2017-05-17)
The patterning of repeated structures is a major theme in developmental biology, and the inter-relationship between spacing and size of such structures is an unresolved issue. Fungiform papillae are repeated epithelial structures that house taste buds on the anterior tongue.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML1314-5MG | 04061833225660 |
| SML1314-1MG | 04061837107832 |
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