SML1314
SAG 二盐酸盐
≥98% (HPLC), lyophilized solid, smoothened (Smo) agonist
别名:
3-氯-N-[反式-4-（甲氨基）环己基]-N- [[3-（4-吡啶）苯基] 甲基]-苯并 [b] 噻吩-2-甲酰胺 二盐酸盐, Smoothened 激动剂
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关于此项目
经验公式（希尔记法）:
C28H28ClN3OS · 2HCl
化学文摘社编号:
分子量:
562.98
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
产品名称
SAG 二盐酸盐, ≥98% (HPLC)
SMILES string
O=C(C1=C(Cl)C2=C(C=CC=C2)S1)N([C@@]3([H])CC[C@@](NC)([H])CC3)CC4=CC(C5=CC=NC=C5)=CC=C4
InChI
1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3/t22-,23-
InChI key
VFSUUTYAEQOIMW-YHBQERECSA-N
assay
≥98% (HPLC)
form
lyophilized solid
storage condition
desiccated
color
white to beige
solubility
H2O: 20 mg/mL, clear
storage temp.
−20°C
Quality Level
Application
Smoothened激动剂(SAG)二盐酸盐作为音猬因子(sonic hedgehog, SHH)通路激动剂已用于：
- 研究其对小鼠海马体细胞的影响
- 研究其对斑马鱼胚胎线粒体网络的影响
- 研究其对鼠胚胎成纤维细胞的影响
Biochem/physiol Actions
SAG 是一种强效且具有细胞渗透性的 smoothened (Smo) 激动剂。
SAG 是一种强效且具有细胞渗透性的 smoothened (Smo) 激动剂，可激活 Hedgehog 途径，抵消环巴胺对 Smo 的抑制。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 4
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Lina Zhu et al.
PeerJ, 10, e13381-e13381 (2022-05-10)
Smoothened (SMO) protein is a member of the G protein-coupled receptor (GPCR) family that is involved in the Hedgehog (Hh) signaling pathway. It is a putative target for treating various cancers, including medulloblastoma and basal cell carcinoma (BCC). Characterizing membrane
Shirin Farheen et al.
Journal of biochemical and molecular toxicology, 37(2), e23241-e23241 (2022-10-08)
Glioma is a major brain tumor, and the associated mortality rate is very high. Contemporary therapies provide a chance of survival for 9-12 months. Therefore, a novel approach is essential to improve the survival rate. Sonic hedgehog (Shh) cell signaling
Alp Ozgun et al.
Materials today. Bio, 25, 100992-100992 (2024-02-19)
Modern in vitro technologies for preclinical research, including organ-on-a-chip, organoids- and assembloid-based systems, have rapidly emerged as pivotal tools for elucidating disease mechanisms and assessing the efficacy of putative therapeutics. In this context, advanced in vitro models of Parkinson's Disease
Michaela Prochazkova et al.
Development (Cambridge, England), 144(12), 2212-2221 (2017-05-17)
The patterning of repeated structures is a major theme in developmental biology, and the inter-relationship between spacing and size of such structures is an unresolved issue. Fungiform papillae are repeated epithelial structures that house taste buds on the anterior tongue.
Suping Qin et al.
Behavioural brain research, 367, 91-100 (2019-04-04)
Obesity induces hippocampal neuronal apoptosis and leads to cognitive function deficits. Sonic hedgehog (SHH) signaling is crucial during nervous system development and is neuroprotective in many neurologic diseases. This study assessed the role of SHH signaling in the cognitive deficits
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