SML1440
硫氯酚
98% (HPLC)
别名:
2,2′-硫代双(4,6-二氯苯酚), 双(2-羟基-3,5-二氯苯)硫醚
方案
98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 20 mg/mL, clear
储存温度
2-8°C
SMILES字符串
Oc1c(Cl)cc(Cl)cc1Sc2cc(Cl)cc(Cl)c2O
InChI
1S/C12H6Cl4O2S/c13-5-1-7(15)11(17)9(3-5)19-10-4-6(14)2-8(16)12(10)18/h1-4,17-18H
InChI key
JFIOVJDNOJYLKP-UHFFFAOYSA-N
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生化/生理作用
硫双二氯酚最初被用作驱虫药。 最近研究表明硫双二氯酚可作为抗卵巢癌的潜在药物，并可能作为阿尔茨海默症的治疗方法。 硫双二氯酚可抑制Aβ42的聚集能力和原纤维的生长，稳定弥散性淀粉样斑块，并在阿尔茨海默症的转基因小鼠模型中降低Aβ42寡聚体的水平，同时改善突触损失、神经元损伤和星形胶质细胞增生。 星形胶质细胞增生可能通过几种作用机理起作用，其中包括氧化磷酸化的解偶联、ROS生成、NF-κB抑制、自分泌抑制素抑制、以及作为Slack钠激活的钾（KNa）通道的激活剂。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Simona Eleuteri et al.
Neurobiology of disease, 74, 144-157 (2014-09-01)
Aβ accumulation plays a central role in the pathogenesis of Alzheimer's disease (AD). Recent studies suggest that the process of Aβ nucleated polymerization is essential for Aβ fibril formation, pathology spreading and toxicity. Therefore, targeting this process represents an effective
Leonard K Kaczmarek
ISRN neuroscience, 2013(2013) (2013-12-10)
The
Vijayalakshmi N Ayyagari et al.
BMC cancer, 14, 61-61 (2014-02-06)
Drug resistance is a cause of ovarian cancer recurrence and low overall survival rates. There is a need for more effective treatment approaches because the development of new drug is expensive and time consuming. Alternatively, the concept of 'drug repurposing'
Dan Zhang et al.
Food chemistry, 237, 1202-1208 (2017-08-03)
A reliable and highly sensitive screening method based on liquid chromatography coupled withtriple-quadrupoleelectrospray tandemmass spectrometry (LC-MS/MS) analysis has been developed for the detection and quantification of three veterinary drugs, including buparvaquone, nystatin, and etomidate impurity B CRS. The tested drugs
Sven B Hinca et al.
Journal of neurochemistry, 157(6), 1861-1875 (2020-10-08)
The endothelial cells of the blood-brain barrier participate in the regulation of glutamate concentrations in the brain interstitial fluid by taking up brain glutamate. However, endothelial glutamate metabolism has not been characterized, nor is its role in brain glutamate homeostasis
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