SML1493
Suprafenacine
≥98% (HPLC)
别名:
4,5,6,7-Tetrahydro-1H-indazole-3-carboxylic acid (2E)-2-[(4-methylphenyl)methylene]hydrazide, 4,5,6,7-Tetrahydro-1H-indazole-3-carboxylic acid [1p-tolyl-meth-(E)-ylidene]-hydrazide, SRF
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 10 mg/mL, clear
储存温度
2-8°C
InChI
1S/C16H18N4O/c1-11-6-8-12(9-7-11)10-17-20-16(21)15-13-4-2-3-5-14(13)18-19-15/h6-10H,2-5H2,1H3,(H,18,19)(H,20,21)/b17-10+
InChI key
WKKLZIQHOXPLLZ-LICLKQGHSA-N
生化/生理作用
Suprafenacine is a cell permeable and potent microtubule destabilizing agent that induces cell cycle arrest in the G2/M phase and apoptotic cell death. Suprafenacine binds to microtubules at the colchicine-binding and inhibits polymerization. Suprafenacine is selective for cancer cells including drug-resistant cancer cells. Apparently, Suprafenacine bypasses the multidrug resistance transporter P-glycoprotein (PGP).
Suprafenacine is a cell permeable and potent microtubule destabilizing agent.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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