SML1520
GS39783
≥98% (HPLC)
别名:
GS-39783, N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine, N4,N6-dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine
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选择尺寸
关于此项目
经验公式（希尔记法）:
C15H23N5O2S
化学文摘社编号:
分子量:
337.44
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
InChI
1S/C15H23N5O2S/c1-23-15-18-13(16-10-6-2-3-7-10)12(20(21)22)14(19-15)17-11-8-4-5-9-11/h10-11H,2-9H2,1H3,(H2,16,17,18,19)
SMILES string
CSc1nc(NC2CCCC2)c(c(NC3CCCC3)n1)[N+]([O-])=O
InChI key
GSGVDKOCBKBMGG-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
faintly yellow to dark yellow
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
room temp
Biochem/physiol Actions
GS39783 is a positive allosteric modulator (PAM) of GABA-B receptors. GABAB receptor positive allosteric modulators have potential for treatment of many neuro-psychiatric disorders as well as drug dependence and seizures. The receptor is a GPCR expressed throughout the CNS; it acts as both an auto-receptor and heteroreceptor to modulate GABA release and regulate K+ channels and Ca++ channels. GS39783 has been shown to inhibit alcohol self-administration and to have an antipsychotic-like effect in animal models of addiction and schizophrenia, respectively.
Positive allosteric modulator of GABAB receptors
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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