SML1582
BMS-3
≥95% (HPLC)
别名:
N-[5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-cyclopropanecarboxamide
InChI
1S/C17H12Cl2F2N4OS/c18-9-2-1-3-10(19)14(9)25-12(6-11(24-25)15(20)21)13-7-22-17(27-13)23-16(26)8-4-5-8/h1-3,6-8,15H,4-5H2,(H,22,23,26)
InChI key
YBGGBHCJSAEIAS-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
powder
color
white to light brown
solubility
DMSO: 10 mg/mL, clear
storage temp.
−20°C
General description
LIMK1 (LIM domain kinase 1) belongs to the serine-threonine protein kinases. The gene is mapped to human chromosome 7q11.
Biochem/physiol Actions
BMS-3 shows cytotoxic effects not related to LIMK, but rather through reduction of the levels of tubulin transcripts and induction of mitotic arrest.
It is a specific inhibitor of LIMK1. LIMK1 is responsible for the inactivation of cofilin (ADF family protein), leading to actin reorganization. It is upregulated in several invasive cancers.
Potent inhibitor of the LIM kinase 1 and 2 (LIMK1/2)
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 4
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Puxiang Chen et al.
Oncology reports, 32(5), 2070-2076 (2014-09-06)
LIM kinase 1 (Limk1) is associated with cell prolife-ration and metastasis and its dysregulated expression has been observed in many types of cancer. The present study aimed to examine the role of Limk1 in the development of ovarian cancer, as
D W Martindale et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 11(10), 890-898 (2000-09-26)
Williams syndrome (WS) is a complex neurodevelopmental disorder arising from a microdeletion at Chr band 7q11.23, which results in a hemizygous condition for a number of genes. Within this region we have completely characterized 200 kb containing the genes LIMK1
Ana Romarowski et al.
Developmental biology, 405(2), 237-249 (2015-07-15)
Mammalian sperm must acquire their fertilizing ability after a series of biochemical modifications in the female reproductive tract collectively called capacitation to undergo acrosomal exocytosis, a process that is essential for fertilization. Actin dynamics play a central role in controlling
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