SML1585
ML116
≥95% (HPLC)
别名:
4-Benzyl-1-{thieno[2,3-d]pyrimidin-4-yl}piperidine, 4-[4-(Phenylmethyl)-1-piperidinyl]-thieno[2,3-d]pyrimidine, CID 2100018
InChI
1S/C18H19N3S/c1-2-4-14(5-3-1)12-15-6-9-21(10-7-15)17-16-8-11-22-18(16)20-13-19-17/h1-5,8,11,13,15H,6-7,9-10,12H2
InChI key
AJQCKNBBHOVJGO-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
powder
color
white to brown
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
room temp
General description
The gene STAT3 (signal transducer and activator of transcription 3) is mapped to human chromosome 17q21. The protein contains a SH2 (src homology 2) domain.
Biochem/physiol Actions
ML116 is a potent and selective inhibitor of STAT3 (signal transducer and activator of transcription 3) phosphorylation. ML116 potently inhibits growth and induces cell death of rodent and human glioma cells. ML116 is inactive against the related STAT1 and NFkB anti-targets.
ML116 is a potent and selective inhibitor of STAT3.
STAT3 is a transcription factor which is activated by cytokines and growth factors. It is oncogenic and is present in various cancers, such as breast, prostate, renal cell, melanoma, ovarian, lung, leukemia, lymphoma and myelomas. It is associated with cellular growth, survival and malignancy.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Hikmat H Assi et al.
The Journal of pharmacology and experimental therapeutics, 349(3), 458-469 (2014-04-04)
Signal transducer and activator of transcription 3 (STAT3) has been implicated as a hub for multiple oncogenic pathways. The constitutive activation of STAT3 is present in several cancers, including gliomas (GBMs), and is associated with poor therapeutic responses. Phosphorylation of
Aijaz Parray et al.
Biologics : targets & therapy, 6, 267-276 (2012-09-08)
The treatment landscape for patients with castration-resistant prostate cancer (CRPC) is undergoing significant changes with the advent of new therapies and multidisciplinary efforts by scientists and clinicians. As activation of multiple molecular pathways in the neoplastic prostate makes it impossible
E Y M G Fung et al.
Genes and immunity, 10(2), 188-191 (2008-12-27)
As a result of genome-wide association studies in larger sample sets, there has been an increase in identifying genes that influence susceptibility to individual immune-mediated diseases, as well as evidence that some genes are associated with more than one disease.
Huang Shao et al.
Cancer research, 63(14), 3923-3930 (2003-07-23)
The oncogene signal transducer and activator of transcription 3 (Stat3) is constitutively activated in a wide variety of human cancers, including squamous cell carcinoma of the head and neck. In squamous cell carcinoma of the head and neck, Stat3 activation
Y T Tsai et al.
Molecular and cellular biology, 20(6), 2043-2054 (2000-02-25)
Etk (also called Bmx) is a member of the Btk tyrosine kinase family and is expressed in a variety of hematopoietic, epithelial, and endothelial cells. We have explored biological functions, regulators, and effectors of Etk. Coexpression of v-Src and Etk
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