SML1660
NA-17
≥98% (HPLC)
别名:
2-[2-(1,3-Benzodioxol-5-yl)ethyl]-6-[[3-(dimethylamino)propyl]amino]-1H-benz[de]isoquinoline-1,3(2H)-dione, 6-(1,3-Propanediamine-N,N-dimethyl-N’-)-N’’-(3,4-methylenedioxy-phenethylamin)-1,8-naphthalimide
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关于此项目
经验公式（希尔记法）:
C26H27N3O4
化学文摘社编号:
分子量:
445.51
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
表单
powder
颜色
light yellow to orange
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
CN(C)CCCNC1=CC=C(C(N(CCC2=CC=C(OCO3)C3=C2)C4=O)=O)C5=C4C=CC=C51
InChI
1S/C26H27N3O4/c1-28(2)13-4-12-27-21-9-8-20-24-18(21)5-3-6-19(24)25(30)29(26(20)31)14-11-17-7-10-22-23(15-17)33-16-32-22/h3,5-10,15,27H,4,11-14,16H2,1-2H3
InChI key
ACOYDEZACFFCPN-UHFFFAOYSA-N
生化/生理作用
NA-17 is a fluorescent naphthalimide that induces accumulation of activated p53 in mitochondria and nuclei of NSCLC cells.
NA-17 is a fluorescent naphthalimide that induces accumulation of activated p53 in mitochondria and nuclei of NSCLC cells. NA-17 reorganizes the Bak–Bcl-xl complex, promotes p53 phosphorylation without altering the expression of p53, induces cell cycle arrest at the G1 phase and apoptosis. NA-17 exhibits potent anticancer activities in multiple cancer cell lines showing low toxicity to normal cell lines.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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