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Merck
CN

SML1741

TH1020

≥95% (HPLC)

别名:

4-((4-苄基-5-(吡啶-4-基)-4H-1,2,4-三唑-3-基)硫基]吡啶基[3 ′,2′,4, 5]-噻吩并[3,2-d]嘧啶, 4-[[4-(苯甲基)-5-(4-吡啶基)-4H-1,2,4-三唑-3-基]硫基]-吡啶基[3′,2′:4 ,5]噻吩并[3,2-d]嘧啶

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关于此项目

经验公式（希尔记法）:
C23H15N7S2
化学文摘社编号:
1841460-82-9
分子量:
453.54
UNSPSC Code:
51111800
PubChem Substance ID:
329826048
NACRES:
NA.77

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InChI key

CBBXTGWSGPEJEE-UHFFFAOYSA-N

InChI

1S/C23H15N7S2/c1-2-5-15(6-3-1)13-30-20(16-8-11-24-12-9-16)28-29-23(30)32-22-19-18(26-14-27-22)17-7-4-10-25-21(17)31-19/h1-12,14H,13H2

SMILES string

C1(C2=CC=NC=C2)=NN=C(SC3=NC=NC4=C3SC5=C4C=CC=N5)N1CC6=CC=CC=C6

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 3 mg/mL, clear (warmed)

storage temp.

2-8°C

Quality Level

100

相关类别

Application

TH1020已用于抑制猪肠单层上皮细胞和小鼠中的toll样受体5(TLR5)。

Biochem/physiol Actions

TH1020介导肿瘤坏死因子-α(TNF-α)相关信号传导的抑制，它通过结合TLR5二聚体之间的分子界面以破坏四聚体复合物的形成。
TH1020是一种无细胞毒性的无细胞毒性toll样受体5（TLR5）/鞭毛蛋白复合物抑制剂。
TH1020是一种无细胞毒性的无细胞毒性toll样受体5（TLR5）/鞭毛蛋白复合物抑制剂。TH1020可选择地阻止鞭毛蛋白诱导的TLR5信号转导，而不影响配体诱导的TLR2、TLR3、TLR4、TLR7或TLR8的激活。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000512669
0000512669
0000486704
0000486704
0000392119

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ChemMedChem, 11(8), 822-826 (2015-12-05)
Protein-protein interactions have been regarded as "undruggable" despite their importance in many biological processes. The complex formed between host toll-like receptor 5 (TLR5) and flagellin, a globular protein that is the main component of a bacterial flagellum, plays a vital role
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