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Merck
CN

SML1872

Sigma-Aldrich

ORM-3819

≥98% (HPLC)

别名:

4-Hydroxy-3-methoxy-2-nitro-benzaldehyde 2-[4-[(4R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazone, L-6-{4-[N′-(4-Hydroxi-3-methoxy-2-nitro-benzylidene)-hydrazino]-phenyl}-5-methyl-4,5-dihydro-2 H-pyridazin-3-one

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关于此项目

经验公式（希尔记法）:
C19H19N5O5
化学文摘社编号:
360794-85-0
分子量:
397.38
UNSPSC代码:
12352202

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方案

≥98% (HPLC)

表单

powder

颜色

light orange to dark orange

溶解性

DMSO: 30 mg/mL, clear

储存温度

2-8°C

SMILES字符串

O=C(C[C@H]1C)NN=C1C(C=C2)=CC=C2NN=CC3=C([N+]([O-])=O)C(OC)=C(O)C=C3

生化/生理作用

ORM-3819 is a potent inotropic agent that binds to cardiac troponin C (cTnC) and sensitizes heart to Ca2+.
ORM-3819 is a potent inotropic agent that binds to cardiac troponin C (cTnC) and sensitizes heart to Ca2+. Also, ORM-3819 is a selective and potent inhibitor of PDE III. ORM-3819 exhibits positive inotropic effects through Ca2+-sensitization and selective inhibition of PDE III. ORM-3819 was effective in vivo dog model of myocardial stunning.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
017M4626V

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László Nagy et al.
European journal of pharmacology, 775, 120-129 (2016-02-14)
This study is the first pharmacological characterization of the novel chemical entity, ORM-3819 (L-6-{4-[N'-(4-Hydroxi-3-methoxy-2-nitro-benzylidene)-hydrazino]-phenyl}-5-methyl-4,5-dihydro-2H-pyridazin-3-one), focusing primarily on its cardiotonic effects. ORM-3819 binding to cardiac troponin C (cTnC) was confirmed by nuclear magnetic resonance spectroscopy, and a selective inhibition of the

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