SML1878
GNF-1331
≥98% (HPLC)
别名:
N-(6-Methoxy-2-benzothiazolyl)-2-[[4-propyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-acetamide
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关于此项目
经验公式（希尔记法）:
C20H20N6O2S2
化学文摘社编号:
分子量:
440.54
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
GNF-1331, ≥98% (HPLC)
InChI
1S/C20H20N6O2S2/c1-3-10-26-18(13-6-8-21-9-7-13)24-25-20(26)29-12-17(27)23-19-22-15-5-4-14(28-2)11-16(15)30-19/h4-9,11H,3,10,12H2,1-2H3,(H,22,23,27)
SMILES string
CCCN1C(SCC(NC2=NC3=C(C=C(OC)C=C3)S2)=O)=NN=C1C4=CC=NC=C4
InChI key
JIUFLMSAFMXEEC-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
Biochem/physiol Actions
GNF-1331 is an orally available, potent and selective Porcupine (PORCN) inhibitor.
GNF-1331 is an orally available, potent and selective Porcupine inhibitor.
存储类别
11 - Combustible Solids
wgk
WGK 3
法规信息
新产品
此项目有
Dai Cheng et al.
ACS medicinal chemistry letters, 7(7), 676-680 (2016-07-21)
Blockade of aberrant Wnt signaling is an attractive therapeutic approach in multiple cancers. We developed and performed a cellular high-throughput screen for inhibitors of Wnt secretion and pathway activation. A lead structure (GNF-1331) was identified from the screen. Further studies
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