SML1895
PBOX-15
≥98% (HPLC)
别名:
4-Acetoxy-5-(1-naphthyl) naphtho[2,3-b]pyrrolo[2,1-d][1,4]oxazepine, PBOX15, Pyrrolo-1,5-benzoxazepine-15
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 15 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CC(OC1=C(C2=CC=CC3=C2C=CC=C3)OC4=C(N5C1=CC=C5)C=C6C=CC=CC6=C4)=O
InChI
1S/C28H19NO3/c1-18(30)31-28-24-14-7-15-29(24)25-16-20-9-2-3-10-21(20)17-26(25)32-27(28)23-13-6-11-19-8-4-5-12-22(19)23/h2-17H,1H3
InChI key
STVDRIIZTGYIMM-UHFFFAOYSA-N
生化/生理作用
A tubulin-targeting, anti-microtubule agent that induces apoptosis in cancer cells, including those exhibiting multi-drug resistance.
PBOX-15 belongs to a group of tubulin-targeting pyrrolo-1,5-benzoxazepine (PBOX) compounds that potently induce apoptosis in a wide spectrum of cancer cells, including those originating from the four main types of leukemia and those exhibiting multi-drug resistance (IC50 = 155 nM/HL60-MDR1, 252 nM/HL60-ABCG2, 210 nM/HL60). PBOX-15 inhibits the assembly of purified tubulin in cell-free assays and causes microtubule depolymerization in MCF-7 cells.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
Seema-Maria Nathwani et al.
International journal of oncology, 49(1), 74-88 (2016-05-14)
Apoptotic defects are frequently associated with poor outcome in pediatric acute lymphoblastic leukaemia (ALL) hence there is an ongoing demand for novel strategies that counteract apoptotic resistance. The death ligand TRAIL (tumour necrosis factor-related apoptosis-inducing ligand) and its selective tumour
Jude M Mulligan et al.
Molecular pharmacology, 70(1), 60-70 (2006-03-31)
We have demonstrated previously that certain members of a series of novel pyrrolo-1,5-benzoxazepine (PBOX) compounds potently induce apoptosis in a variety of human chemotherapy-resistant cancer cell lines and in primary ex vivo material derived from cancer patients. A better understanding
Paula Kinsella et al.
Investigational new drugs, 34(2), 159-167 (2016-02-18)
The C-KIT receptor tyrosine kinase is constitutively activated in the majority of gastrointestinal stromal tumours (GIST). Imatinib (IM) a selective inhibitor of C-KIT, is indicated for the treatment of KIT-positive unresectable and/or metastatic GIST, and has tripled the survival time
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