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Merck
CN

SML1934

Sigma-Aldrich

DR4004 hydrochloride

≥98% (HPLC)

别名:

1-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-butyl]-2a,3,4,5-tetrahydro-1H-benzo[cd]indol-2-one, 2a-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-2a,3,4,5-tetrahydrobenz[cd]indol-2(1H)-one, DR 4004

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关于此项目

经验公式(希尔记法):
C26H30N2O · HCl
化学文摘社编号:
分子量:
422.99
UNSPSC代码:
12352200
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质量水平

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

H2O: 2 mg/mL, clear (warmed)

储存温度

2-8°C

生化/生理作用

DR4004 is a potent and selective 5-HT7 serotonin receptor antagonist.
Potent and selective 5-HT7 serotonin receptor antagonist

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Hiroshi Takeda et al.
European journal of pharmacology, 518(1), 30-39 (2005-07-09)
The present study examined whether serotonin (5-hydroxytryptamine; 5-HT)7 receptors play a role in the modulation of emotionality in mice using the selective 5-HT7 receptor antagonist 2a-[4-(4-phenyl-1,2,3,6-tetrahydropyridyl)butyl]-2a,3,4,5-tetrahydrobenzo (c,d)indol-2-(1H)-one (DR4004). The emotionality of mice was evaluated in terms of exploratory activity in
Kotaro Takeda et al.
Neuroscience letters, 638, 69-75 (2016-12-13)
Fear conditioning is a valuable behavioral paradigm for studying the neural basis of emotional learning and memory. The present study examined the involvement of extracellular signal-regulated kinase 1/2 (ERK) signaling on the serotonin (5-HT)
Kazumasa Horikawa et al.
Journal of pharmacological sciences, 123(4), 402-406 (2013-12-03)
Several lines of evidence indicate that serotonin type 7 (5-HT7) receptors play a critical role for non-photic resetting of the mammalian circadian clock; however, the contributions of other types of 5-HT receptors to non-photic entrainment are not yet clarified. The

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