SML1966
SK609 hydrochloride
≥98% (HPLC)
别名:
4-(2-Chlorophenyl)butan-2-amine hydrochloride, ES609, SK609•HCl
方案
≥98% (HPLC)
表单
powder
储存条件
protect from light
under inert gas
颜色
white to beige
溶解性
H2O: 2 mg/mL, clear
储存温度
2-8°C
相关类别
生化/生理作用
Dopamine D3 receptor (D3R) selective agonist
SK609 (ES609) is a Dopamine D3 receptor (D3R) selective agonist with a bias towards the G-protein-dependent pathway rather than recruiting β-arrestin-2 and an EC50 value of 113.9 nM for activation of ERK1/2 phosphorylation. SK609 has been shown to reverse akinesia and reduce L-dopa-induced dyskinesia in a hemiparkinsonian rat model of Parkinson′s desease. It does not induce desensitization of D3R.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Sherise L Simms et al.
Neuropharmacology, 100, 106-115 (2015-04-22)
Synthetic dopaminergic agents have found utility in treating neurological and neuropsychiatric disorders since the beginning of 19th century. The discovery of Levodopa (l-dopa) to effectively treat motor symptoms of Parkinson's disease (PD) revolutionized the therapy and remains a gold standard
Wei Xu et al.
ACS chemical neuroscience, 8(3), 486-500 (2016-11-02)
Dopamine receptors play an integral role in controlling brain physiology. Importantly, subtype selective agonists and antagonists of dopamine receptors with biased signaling properties have been successful in treating psychiatric disorders with a low incidence of side effects. To this end
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