SML2007
PMI
≥98% (HPLC)
别名:
1-(3-Iodophenyl)-4-(3-nitrophenyl)-1H-1,2,3-triazole, HB229, P62-Mediated mitophagy inducer
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
Ic1cc(ccc1)[n]2nnc(c2)c3cc(ccc3)[N+](=O)[O-]
InChI key
LSVWEYNSNZJEGB-UHFFFAOYSA-N
生化/生理作用
P62-mediated mitophagy inducer
PMI is a p62-mediated mitophagy inducer. It is believed to upregulate the major autophagy receptor ubiquitin-binding protein p62 (also named sequestosome 1/SQSTM1) via stabilization of Nrf2. PMI was shown to induce Nrf2 dependent gene products and inhibit the Keap1?Nrf2 protein?protein interaction while being partially dependent upon Parkin and PINK1.
警示用语：
Danger
危险声明
危险分类
Self-react. C
储存分类代码
5.2 - Organic peroxides and self-reacting hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Hélène C Bertrand et al.
Journal of medicinal chemistry, 58(18), 7186-7194 (2015-09-09)
The transcription factor Nrf2 regulates the expression of a large network of cytoprotective and metabolic enzymes and proteins. Compounds that directly and reversibly inhibit the interaction between Nrf2 and its main negative regulator Keap1 are potential pharmacological agents for a
Nikolaos D Georgakopoulos et al.
Nature chemical biology, 13(2), 136-146 (2017-01-20)
Small molecules are pharmacological tools of considerable value for dissecting complex biological processes and identifying potential therapeutic interventions. Recently, the cellular quality-control process of mitophagy has attracted considerable research interest; however, the limited availability of suitable chemical probes has restricted
Daniel A East et al.
Chemistry & biology, 21(11), 1585-1596 (2014-12-03)
Mitophagy is central to mitochondrial and cellular homeostasis and operates via the PINK1/Parkin pathway targeting mitochondria devoid of membrane potential (ΔΨm) to autophagosomes. Although mitophagy is recognized as a fundamental cellular process, selective pharmacologic modulators of mitophagy are almost nonexistent.
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