SML2283
来那度胺
≥98% (HPLC), powder, cereblon binder
别名:
来那度胺, 1-氧-4-氨基-2-(2,6-二氧哌啶-3-基)异吲哚, 3-(4-氨基-1,3-二氢-1-氧代-2H-异吲哚-2-基)-2,6-哌啶二酮, 3-(4-氨基-1-氧代异吲哚-2-基)哌啶-2,6-二酮, CC 5013, CC-5013
产品名称
来那度胺, ≥98% (HPLC)
ligand
lenalidomide
方案
≥98% (HPLC)
表单
powder
反应适用性
reagent type: ligand
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O=C1N(C2CCC(NC2=O)=O)CC3=C1C=CC=C3N
InChI
1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)
InChI key
GOTYRUGSSMKFNF-UHFFFAOYSA-N
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生化/生理作用
来那度胺，沙利度胺的一种衍生物，是经批准可用于治疗多发性骨髓瘤的一种免疫调节剂。显然，来那度胺是泛素E3连接酶cereblon的一种配体，可诱导该酶降解Ikaros转录因子IKAROS家族锌指1（IKZF1）和IKZF3。来那度胺具有多效抗肿瘤作用。它可用于治疗5q缺失相关骨髓增生异常综合症（del(5q)-MDS）。
警示用语：
Danger
危险声明
危险分类
Repr. 1B - STOT RE 2
靶器官
Blood
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome
Donovan KA, et al.
eLife, 7, e38430-e38430 (2018)
Amanda C Ritter et al.
Comparative medicine, 73(2), 153-172 (2023-03-28)
Mouse kidney parvovirus (MKPV) causes inclusion body nephropathy in severely immunocompromised mice and renal interstitial inflammation in immunocompetent mice. Here we sought to determine the effects of MKPV on pre-clinical murine models that depend on renal function. To assess the
Yuan Xiao Zhu et al.
Blood, 118(18), 4771-4779 (2011-08-24)
The precise molecular mechanism of action and targets through which thalidomide and related immunomodulatory drugs (IMiDs) exert their antitumor effects remains unclear. We investigated the role of cereblon (CRBN), a primary teratogenic target of thalidomide, in the antimyeloma activity of
Hila Shaim et al.
Frontiers in immunology, 8, 1773-1773 (2018-01-31)
Chronic lymphocytic leukemia (CLL) cells possess regulatory functions comparable to those of normal B10 cells, a regulatory B cell subset that suppresses effector T-cell function through STAT3-mediated IL-10 production. However, the mechanisms governing IL-10 production by CLL cells are not
Georg Petzold et al.
Nature, 532(7597), 127-130 (2016-02-26)
Thalidomide and its derivatives, lenalidomide and pomalidomide, are immune modulatory drugs (IMiDs) used in the treatment of haematologic malignancies. IMiDs bind CRBN, the substrate receptor of the CUL4-RBX1-DDB1-CRBN (also known as CRL4(CRBN)) E3 ubiquitin ligase, and inhibit ubiquitination of endogenous
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