方案
≥95% (HPLC)
表单
powder
颜色
yellow to brown
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O=C(/C1=N\O)NC(C1=C2)=CC=C2C34C[C@@H](C5)C[C@@H](C[C@@H]5C4)C3
生化/生理作用
ADA-07 is a potent and selective T-LAK cell-originated protein kinase (TOPK) inhibitor that binds to ATP-binding pocket. ADA-07 suppresses SUV-induced phosphorylation of ERK1/2, p38, and JNKs and subsequently inhibited AP-1 activity, and reduces SUV-induced skin carcinogenesis.
potent and selective TOPK inhibitor that binds to ATP-binding pocket; reduces SUV-induced skin carcinogenesis
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
Ge Gao et al.
Molecular cancer therapeutics, 16(9), 1843-1854 (2017-06-29)
Cumulative exposure to solar ultraviolet (SUV) irradiation is regarded as the major etiologic factor in the development of skin cancer. The activation of the MAPK cascades occurs rapidly and is vital in the regulation of SUV-induced cellular responses. The T-LAK
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