SML2666
Diflapolin
≥98% (HPLC)
别名:
N-[4-(2-Benzothiazolylmethoxy)-2-methylphenyl]-N′-(3,4-dichlorophenyl)-urea, N-[4-(Benzothiazol-2-ylmethoxy)-2-methylphenyl]-N′-(3,4-dichlorophenyl)urea
InChI
1S/C22H17Cl2N3O2S/c1-13-10-15(29-12-21-26-19-4-2-3-5-20(19)30-21)7-9-18(13)27-22(28)25-14-6-8-16(23)17(24)11-14/h2-11H,12H2,1H3,(H2,25,27,28)
InChI key
FGXLEECGXSDIMM-UHFFFAOYSA-N
SMILES string
O=C(NC1=CC=C(Cl)C(Cl)=C1)NC2=C(C)C=C(OCC3=NC4=CC=CC=C4S3)C=C2
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Diflapolin is a bioavailable, highly potent and highly selective dual FLAP/sEH (5-LO-activating protein/ soluble epoxide hydrolase) inhibitor that suppresses leukotriene formation and increases epoxyeicosatrienoic acids levels. Diflapolin exhibit potent anti-inflammatory activities in mice models.
bioavailable, highly potent and highly selective dual FLAP/sEH (5-LO-activating protein/ soluble epoxide hydrolase) inhibitor
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Lisa Vieider et al.
ACS medicinal chemistry letters, 10(1), 62-66 (2019-01-19)
A series of derivatives of the potent dual soluble epoxide hydrolase (sEH)/5-lipoxygenase-activating protein (FLAP) inhibitor diflapolin was designed, synthesized, and characterized by 1H NMR, 13C NMR, and elemental analysis. These novel compounds were biologically evaluated for their inhibitory activity against
Veronika Temml et al.
Scientific reports, 7, 42751-42751 (2017-02-22)
Leukotrienes (LTs) are pro-inflammatory lipid mediators derived from arachidonic acid (AA) with roles in inflammatory and allergic diseases. The biosynthesis of LTs is initiated by transfer of AA via the 5-lipoxygenase-activating protein (FLAP) to 5-lipoxygenase (5-LO). FLAP inhibition abolishes LT
Ulrike Garscha et al.
Scientific reports, 7(1), 9398-9398 (2017-08-26)
Arachidonic acid (AA) is metabolized to diverse bioactive lipid mediators. Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs). Accordingly, dual FLAP/sEH inhibition might
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