SML2864
Loviride
≥98% (HPLC)
别名:
α-[(2-Acetyl-5-methylphenyl)amino]-2,6-dichloro-benzeneacetamide, (±)-2-(6-Acetyl-m-toluidino)-2-(2,6-dichlorophenyl)acetamide, R 89439
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关于此项目
经验公式（希尔记法）:
C17H16Cl2N2O2
化学文摘社编号:
分子量:
351.23
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
SMILES string
Clc1c(c(ccc1)Cl)C(Nc2c(ccc(c2)C)C(=O)C)C(=O)N
InChI
1S/C17H16Cl2N2O2/c1-9-6-7-11(10(2)22)14(8-9)21-16(17(20)23)15-12(18)4-3-5-13(15)19/h3-8,16,21H,1-2H3,(H2,20,23)
InChI key
CJPLEFFCVDQQFZ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Loviride is an orally available, potent and selective inhibitor of reverse transcriptase HIV-1 that inhibits HIV replication in cells. Also, loviride inhibits replication of HIV-2 and SIV in cells.
Orally available, potent and selective inhibitor of reverse transcriptase HIV-1 that inhibits HIV replication in cells
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Philippe Berben et al.
International journal of pharmaceutics, 537(1-2), 22-29 (2017-12-16)
In view of the increasing interest of pharmaceutical companies for cell- and tissue-free models to implement permeation into formulation testing, this study explored the capability of an artificial membrane insert system (AMI-system) as predictive tool to evaluate the performance of
M Witvrouw et al.
AIDS (London, England), 13(12), 1477-1483 (1999-08-28)
After the initial discovery of 1-(2-hydroxyethoxymethyl)-6-(phenylthio)thymine (HEPT) and tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and thione (TIBO) derivatives, several other non-nucleoside reverse transcriptase (RT) inhibitors (NNRTI), including nevirapine (BI-RG-587), pyridinone derivatives (L-696,229 and L-697,661), delavirdine (U-90152), alpha-anilinophenylacetamides (alpha-APA) and various other classes of NNRTI have
R Pauwels et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(5), 1711-1715 (1993-03-01)
In vitro evaluation of a large chemical library of pharmacologically acceptable prototype compounds in a high-capacity, cellular-based screening system has led to the discovery of another family of human immunodeficiency virus type 1 (HIV-1) inhibitors. Through optimization of a lead
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