SML2890
BAY-899
≥98% (HPLC)
别名:
(5S)-N-[2-(4-Fluorophenoxy)pyrimidin-5-yl]-5-(4-fluorophenyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxamide, (S)-N-(2-(4-Fluorophenoxy)pyrimidin-5-yl)-5-(4-fluorophenyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxamide
质量水平
方案
≥98% (HPLC)
表单
powder
旋光性
[α]/D 165 to 195°, c = 1 in chloroform-d
颜色
white to beige
溶解性
DMSO: 1 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O=C(N1[C@@H](C2=CC=C(F)C=C2)C3=C(N=CC=C3)CC1)NC4=CN=C(OC5=CC=C(F)C=C5)N=C4
InChI
1S/C25H19F2N5O2/c26-17-5-3-16(4-6-17)23-21-2-1-12-28-22(21)11-13-32(23)25(33)31-19-14-29-24(30-15-19)34-20-9-7-18(27)8-10-20/h1-10,12,14-15,23H,11,13H2,(H,31,33)/t23-/m0/s1
InChI key
VKQBTIMLSDGNLG-QHCPKHFHSA-N
生化/生理作用
BAY-899 is an orally available, potent and selective antagonist of the human luteinizing hormone receptor (hLH-R) that reduces sex hormone levels in several animal models. BAY-899 likely binds to a putative rhodopsin-like binding cavity located within the 7-transmembrane region of the hLH-receptor.
orally available, potent and selective antagonist of the human luteinizing hormone receptor (hLH-R)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
Lars Wortmann et al.
Journal of medicinal chemistry, 62(22), 10321-10341 (2019-11-02)
The human luteinizing hormone receptor (hLH-R) is a member of the glycoprotein hormone family of G-protein-coupled receptors (GPCRs), activated by luteinizing hormone (hLH) and essentially involved in the regulation of sex hormone production. Thus, hLH-R represents a valid target for
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