SML2920
Y-39983 dihydrochloride
≥98% (HPLC)
别名:
4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-yl-benzamide dihydrochloride, Y 39983, Y39983
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关于此项目
经验公式（希尔记法）:
C16H16N4O · 2HCl
化学文摘社编号:
分子量:
353.25
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
Y-39983 dihydrochloride, ≥98% (HPLC)
InChI
1S/C16H16N4O.2ClH/c1-10(17)11-2-4-12(5-3-11)16(21)20-14-7-9-19-15-13(14)6-8-18-15;;/h2-10H,17H2,1H3,(H2,18,19,20,21);2*1H/t10-;;/m1../s1
SMILES string
N[C@@H](C1=CC=C(C(NC2=CC=NC3=C2C=CN3)=O)C=C1)C.Cl.Cl
InChI key
CKFHAVRPVZNMGT-YQFADDPSSA-N
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +5 to +9°, c = 1 in methanol
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Y-39983 is a potent and selective Rho-kinase (ROCK) inhibitor (IC50s = 3.6 nM). Y-39983 is 10 fold more potent in promoting the outgrowth of neurites in cultured retinal slices and axonal regeneration in crushed optic nerve models than Y-27632. Y-39983 act also as an activator of the neuroprotective Parkin-mediated mitophagy pathway.
potent and selective rho-associated protein kinase (ROCK) inhibitor
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Kevin G Chen et al.
Journal of visualized experiments : JoVE, (89) (2014-08-01)
Human pluripotent stem cells (hPSCs) hold great promise for regenerative medicine and biopharmaceutical applications. Currently, optimal culture and efficient expansion of large amounts of clinical-grade hPSCs are critical issues in hPSC-based therapies. Conventionally, hPSCs are propagated as colonies on both
Enhua H Zhou et al.
Investigative ophthalmology & visual science, 58(7), 2991-3003 (2017-06-13)
To discover novel therapies that lower IOP by increasing aqueous humor outflow facility, ex vivo ocular perfusion systems provide a valuable tool. However, currently available designs are limited by their throughput. Here we report the development of a compact, scalable
Natalia Moskal et al.
Nature communications, 11(1), 88-88 (2020-01-05)
The accumulation of damaged mitochondria causes the death of dopaminergic neurons. The Parkin-mediated mitophagy pathway functions to remove these mitochondria from cells. Targeting this pathway represents a therapeutic strategy for several neurodegenerative diseases, most notably Parkinson's disease. We describe a
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