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Merck
CN

SML2991

Sigma-Aldrich

Ru265

≥95% (HPLC), powder, mitochondrial calcium uniporter inhibitor

别名:

Ru2(μ-N)(NH3)8Cl2]Cl3, trans,trans-Octaamminedichloro-μ-nitridodi-Ruthenium(3+) trichloride, Nitride, ruthenium complex

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关于此项目

经验公式（希尔记法）:
Cl5H24N9Ru2
CAS Number:
27056-01-5
分子量:
529.66
UNSPSC代码:
12352200
NACRES:
NA.77

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Product Name

Ru265, ≥95% (HPLC)

质量水平

100

方案

≥95% (HPLC)

表单

powder

颜色

white to dark beige

溶解性

H2O: 2 mg/mL, clear

储存温度

2-8°C

SMILES字符串

Cl[Ru](N)(N)(N)(N)n[Ru](N)(N)(N)(N)Cl

相关类别

生化/生理作用

Ru265 is a non-cytotoxic, aqueous soluble nitrido-bridged dinuclear Ru(IV) complex that acts as a selective mitochondrial calcium uniporter (MCU) inhibitor via a manner distinct from the oxo-bridged Ru360. Ru265 selectively reduces 100 μM histamine-induced mitochondrial [Ca2+] (mCa2+), but not cytosolic [Ca2+] (cCa2+) transient (50 ?M; HeLa) by blocking MCU-mediated mCa2+ uptake at a >10-fold greater potency as Ru360 (IC50 ~2.6 nM vs. 30 nM; HEK293T) without effecting mCa2+ efflux or membrane potential (ΔΨm). Ru265 (50 μM) protects neonatal rat ventricular myocytes from hypoxia/reoxygenation injury by preventing mPTP opening and mCa2+ overload.
Selective mitochondrial calcium uniporter (MCU) inhibitor that blocks mitochondrial Ca2+ uptake at a >10-fold greater potency as Ru360.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000473361
0000473361
0000450895
0000450895
0000435404

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Joshua J Woods et al.
Angewandte Chemie (International ed. in English), 59(16), 6482-6491 (2020-02-11)
The mitochondrial calcium uniporter (MCU) is the ion channel that mediates Ca2+ uptake in mitochondria. Inhibitors of the MCU are valuable as potential therapeutic agents and tools to study mitochondrial Ca2+ . The best-known inhibitor of the MCU is the
Robyn J Novorolsky et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 40(6), 1172-1181 (2020-03-05)
The mitochondrial calcium (Ca2+) uniporter (MCU) mediates high-capacity mitochondrial Ca2+ uptake implicated in ischemic/reperfusion cell death. We have recently shown that inducible MCU ablation in Thy1-expressing neurons renders mice resistant to sensorimotor deficits and forebrain neuron loss in a model
Joshua J Woods et al.
ACS central science, 5(1), 153-166 (2019-01-30)
Mitochondrial Ca2+ (mCa2+) uptake mediated by the mitochondrial calcium uniporter (MCU) plays a critical role in signal transduction, bioenergetics, and cell death, and its dysregulation is linked to several human diseases. In this study, we report a new ruthenium complex

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