SML3047
Urolithin C
≥97% (HPLC), Insulin secretion activator, powder
别名:
3,8,9-Trihydroxy-6H-benzo[c]chromen-6-one, 3,8,9-Trihydroxy-6H-dibenzo[b,d]pyran-6-one, 3,8,9-Trihydroxyurolithin
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关于此项目
经验公式（希尔记法）:
C13H8O5
化学文摘社编号:
分子量:
244.20
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
Urolithin C, ≥97% (HPLC)
InChI key
HHXMEXZVPJFAIJ-UHFFFAOYSA-N
SMILES string
O=C1C2=CC(O)=C(O)C=C2C3=C(C=C(O)C=C3)O1
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Urolithin C is chebulic ellagitannins metabolite that exerts antiproliferative and antioxidant activity. Urolithin C exhibit glucose dependent enhancement of insulin secretion in islet cells under normal or dysfunctional conditions. Apparently, it facilitates L-type Ca2+ channel opening and Ca2+ influx into pancreatic β-cells.
chebulic ellagitannins metabolite, exhibit glucose dependent enhancement of insulin secretion
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Inhae Kang et al.
Molecular nutrition & food research, 60(5), 1129-1138 (2016-02-14)
Urolithins (Uro) are ellagic acid (EA)-derived metabolites produced by gut microbes. There is a growing interest in the biological activities of Uro. Our aim was to evaluate the impacts of Uro on regulating triglyceride (TG) accumulation using cultures of primary
Daniil N Olennikov et al.
Nutrients, 7(10), 8456-8477 (2015-10-17)
Chebulic ellagitannins (ChET) are plant-derived polyphenols containing chebulic acid subunits, possessing a wide spectrum of biological activities that might contribute to health benefits in humans. The herbal formulation Padma Hepaten containing ChETs as the main phenolics, is used as a
Xudong Zeng et al.
American journal of translational research, 11(10), 6316-6325 (2019-11-19)
Cardiovascular diseases are the main cause of death and disability among diabetes patients. Atherosclerosis-associated stroke is one of the most severe complications in diabetes patients. DPP-4 inhibitors are a class of potent anti-glycemic agents used to treat diabetes. Recently, some
Morgane Bayle et al.
British journal of pharmacology, 176(20), 4065-4078 (2019-08-06)
The pharmacology of polyphenol metabolites on beta-cell function is largely undetermined. We sought to identify polyphenol metabolites that enhance the insulin-secreting function of beta-cells and to explore the underlying mechanisms. INS-1 beta-cells and rat isolated islets of Langerhans or perfused
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