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Merck
CN

SML3435

Momordin Ιc

≥98% (HPLC)

别名:

(3β)-17-Carboxy-28-norolean-12-en-3-yl 3-O-β-D-xylopyranosyl-β-D-glucopyranosiduronic acid, Mormordin Ic

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关于此项目

经验公式（希尔记法）:
C41H64O13
化学文摘社编号:
96990-18-0
分子量:
764.94
UNSPSC Code:
12352200
NACRES:
NA.77

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SMILES string

O1[C@H]([C@@H]([C@H]([C@@H]([C@H]1C(=O)O)O)O[C@@H]7OC[C@H]([C@@H]([C@H]7O)O)O)O)O[C@@H]2C([C@H]3[C@@]([C@@H]4[C@]([C@@]5(CC[C@@]6([C@@H](CC(CC6)(C)C)C5=CC4)C(=O)O)C)(CC3)C)(CC2)C)(C)C

InChI

1S/C41H64O13/c1-36(2)14-16-41(35(49)50)17-15-39(6)20(21(41)18-36)8-9-24-38(5)12-11-25(37(3,4)23(38)10-13-40(24,39)7)52-34-29(46)30(28(45)31(54-34)32(47)48)53-33-27(44)26(43)22(42)19-51-33/h8,21-31,33-34,42-46H,9-19H2,1-7H3,(H,47,48)(H,49,50)/t21-,22+,23-,24+,25-,26-,27+,28-,29+,30-,31-,33-,34+,38-,39+,40+,41-/m0/s1

InChI key

HWYBGIDROCYPOE-WEAQAMGWSA-N

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D 12 to 17° in methanol (c=0.5 g/100mL)

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Quality Level

100

General description

Momordin Ιc is a pentacyclic triterpenoid isolated from Kochia scoparia (L.) fruit and other medicinal plants.

Biochem/physiol Actions

Momordin Ic is a potent inhibitor of SUMO-specific protease 1 (SENP1) that increases SUMOylated proteins in PC3 cells. It inhibits cell proliferation and induces cell death in prostate cancer PC3 xenograft mouse model. Momordin Ιc decreases serum glucose and ethanol levels after oral administration through acceleration of gastrointestinal transit.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
0000205378
0000205380
0000188979
0000205380
0000205378

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Small-Molecule Inhibitors Targeting Protein SUMOylation as Novel Anticancer Compounds
Yang Y, Xia Z, Wang X, Zhao X, Sheng Z, Ye Y, He G, Zhou L, Zhu H, Xu N, Liang S
Molecular Pharmacology (2018)
Jingjing Wu et al.
Oncotarget, 7(37), 58995-59005 (2016-07-28)
SUMO-specific protease 1 (SENP1), a member of the de-SUMOylation protease family, is elevated in prostate cancer (PCa) cells and is involved in PCa pathogenesis. Momordin Ιc (Mc), a natural pentacyclic triterpenoid, inhibited SENP1 in vitro, as reflected by reduced SENP1C-induced
Y Li et al.
European journal of pharmacology, 392(1-2), 71-77 (2000-04-05)
Possible involvement of 5-hydroxytryptamine (5-HT), 5-HT receptors and prostaglandins in the acceleration of gastrointestinal transit by momordin Ic was investigated in mice. Accelerative effect of momordin Ic (25 mg/kg, p.o.) on gastrointestinal transit was attenuated by pretreatment with a bolus

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