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关于此项目
经验公式（希尔记法）:
C26H32O2
化学文摘社编号:
分子量:
376.53
MDL number:
NACRES:
NA.21
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
-10 to -25°C
General description
Conformationally restricted anti-AP-1 retinoid that selectively induces receptors-mediated AP-1 inhibition, but not transcription activation.
SR11302 is a conformationally restricted anti-AP-1 retinoid that selectively induces receptors-mediated AP-1 inhibition (RARα > RARγ > RXRα = RARβ), but not transcription activation (25-fold vs no RARα enhancement by 1 μM t-RA or 10 μM SR11302, respectively). Unlike t-RA, SR11302 inhibits the proliferation of cancer cultures (1 μM; Calu-6, HeLA, T47D) without inducing the differentiation of F9 cells (0.1-1 μM).
SR11302 is a conformationally restricted anti-AP-1 retinoid that selectively induces receptors-mediated AP-1 inhibition (RARα > RARγ > RXRα = RARβ), but not transcription activation (25-fold vs no RARα enhancement by 1 μM t-RA or 10 μM SR11302, respectively). Unlike t-RA, SR11302 inhibits the proliferation of cancer cultures (1 μM; Calu-6, HeLA, T47D) without inducing the differentiation of F9 cells (0.1-1 μM).
存储类别
11 - Combustible Solids
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable