SML4011
BPTPE
≥98% (HPLC)
别名:
1,1-Bis(4-hydroxyphenyl)-2-phenyl-1-butene, 4,4′-(2-Phenyl-1-butenylidene)bis-phenol, 4,4′-(2-Phenylbut-1-ene-1,1-diyl)diphenol; triphenylethylene bisphenol
生化/生理作用
Potent partial estrogen agonist.
BPTPE, an angular estrogen, is a potent partial estrogen agonist. It induces cell cycle regulated genes that are like those activated by E2 in MCF7 cells. BPTPE exhibits delayed induction of unfolded protein response (UPR) and apoptosis in numerous breast cancer models.
BPTPE, an angular estrogen, is a potent partial estrogen agonist. It induces cell cycle regulated genes that are like those activated by E2 in MCF7 cells. BPTPE exhibits delayed induction of unfolded protein response (UPR) and apoptosis in numerous breast cancer models.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Balkees Abderrahman et al.
Molecular pharmacology, 98(4), 364-381 (2020-08-14)
Long-term estrogen deprivation (LTED) with tamoxifen (TAM) or aromatase inhibitors leads to endocrine-resistance, whereby physiologic levels of estrogen kill breast cancer (BC). Estrogen therapy is effective in treating patients with advanced BC after resistance to TAM and aromatase inhibitors develops.
I E Obiorah et al.
British journal of pharmacology, 171(17), 4062-4072 (2014-05-14)
Triphenylethylene (TPE)-like compounds were the first agents to be used in the treatment of metastatic breast cancer in postmenopausal women. Although structurally related to the anti-oestrogen, 4-hydroxytamoxifen, TPEs possess oestrogenic properties in fully oestrogenized breast cancer cells but do not
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