Fluorosamine

Name: Fluorosamine
Brand: SIGMA

≥98% (HPLC), (liquid to crytals), CSPG synthesis inhibitor

别名:

(3R,4R,5S,6R)-3-Acetamido-6-(acetoxymethyl)-5-fluorotetrahydro-2H-pyran-2,4-diyl diacetate, 2-Acetamido-4-fluoro-1,3,6-tri-o-acetyl-2,4-dideoxy-d-glucopyranose, peracetylated 4-F-GlcNAc, 2-Acetamido-1,3,6-tri-O-acetyl-2,4-dideoxy-4-fluoro-D-glucopyranose, Ac-4-F-GlcNAc

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关于此项目

经验公式（希尔记法）:

C₁₄H₂₀FNO₈

化学文摘社编号:

116049-57-1

分子量:

349.31

Assay:

≥98% (HPLC)

Form:

(liquid to crytals)

Quality level:

100

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Quality Level

100

assay

≥98% (HPLC)

form

(liquid to crytals)

color

white to yellow

storage temp.

2-8°C

General description

Fluorosamine is characterized by its fluorinated glucosamine structure, specifically modified at the 4-position with a fluorine atom. The presence of the fluorine atom is crucial for its inhibitory action on CSPG biosynthesis.

Application

Fluorosamine may be used in in vitro and in vivo models to study the mechanisms underlying remyelination and the role of extracellular matrix components in neural repair.

Biochem/physiol Actions

Fluorosamine (per-O-Acetylated-4-F-N-acetylglucosamine) is a cell-permeable inhibitor of chondroitin sulfate glycosaminoglycan (CS-GAG) chain assembly, reducing chondroitin sulfate proteoglycan (CSPG) activity and perineuronal nets (PNNs) in the arcuate nucleus (ARC). In vitro, at 10 µg/ml, Ac-4-F-GlcNAc significantly reduces neurofibrosis by preventing CS-GAG synthesis and elongation. In vivo, Fluorosamine administered intranasally (1 mg and 5 mg) or intracerebroventricularly (100 µg and 250 µg) depletes GanNAc, improves glycemic control, weight loss, and energy expenditure by restoring ARC insulin sensitivity in obese and diabetic mice. Additionally, it accelerates remyelination and exhibits immunomodulatory properties, reducing T-cell proliferation in CNS models.