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SML4234

Nek1 Inhibitor 10f

Name: Nek1 Inhibitor 10f
Brand: SIGMA

≥98% (HPLC), powder, NIMA Related Kinase 1 inhibitor

别名:

(R)-N-(1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamide, Nek1i-10f, NIMA-related kinase 1 Inhibitor 10f

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关于此项目

经验公式（希尔记法）:

C₂₄H₂₂N₄O₃S

化学文摘社编号:

2727158-07-6

分子量:

446.52

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Application

Nek1 Inhibitor 10f may be used to analyze the effects of NEK1 inhibition on ciliogenesis in zebrafish pronephros. It may also be used to evaluate its efficacy, toxicity, and bioavailability in models of zebrafish polycystic kidney disease.

Biochem/physiol Actions

Nek1 Inhibitor 10f (Nek1i-10f) is a cell-permeable azaindolo-D-tryptophanyl compound that acts as a potent and ATP-competitive Nek1 selective inhibitor (IC50 at 10 µM ATP = 330 nM; 96% inhibition at 1 µM). Nek1 Inhibitor 10f is shown to dominantly affect IKKb activity in a 50-kinase panel. Nek1i-10f is bioavailable, highly efficacious with less toxicity and causes cystic kidneys in zebrafish embryos (10 µM). Nek1-IN-10f reduces NEK1 levels and perturbs nucleocytoplasmic transport in induced pluripotent stem cell motor neurons.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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全球贸易项目编号

货号	GTIN
SML4234-25MG	04065273262360
SML4234-5MG	04065273262377

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