主要文件

查看所有文档

SML4246

Idelalisib

Name: Idelalisib
Brand: SIGMA

≥98% (HPLC), powder, PI3Kδ inhibitor

别名:

CAL 101, CAL-101, CAL101, GS 1101, GS-1101, GS1101, 5-Fluoro-3-phenyl-2-[(S)-1-(9H-purin-6-ylamino)-propyl]-3H-quinazolin-4-one, N6-[(S)-1-(5-Fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl]adenine

登录并加购，请在购物车里查看协议价、货期和发货地。

选择规格

变更视图

关于此项目

经验公式（希尔记法）:

C₂₂H₁₈FN₇O

化学文摘社编号:

870281-82-6

分子量:

415.42

MDL number:

MFCD35086135

NACRES:

NA.21

Assay:

≥98% (HPLC)

Form:

powder

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

说明

Application

Idelalisib may be used to study:

its inhibitory effects on transforming growth factor (TGF) -β2 -stimulated Akt activation, fibronectin expression and collagen gel contraction in human RPE cells
its effects on the anti-tumor action of CDK4/6 inhibitor palbociclib via Polo-like kinase 1 (PLK1) in B-cell lymphoma

Biochem/physiol Actions

Idelalisib (CAL-101; GS-1101) is an orally active, potent and subtype-selective, in vitro and in vivo, phosphatidylinositol-3-kinase p110delta (PI3Kδ) inhibitor (PI3Kδ/γ/β/α IC50 = 2.5/89/565/820 nM, IC50 = 978 nM/hVPS34, 6.73 µM/DNA-PK, >1 µM/CIIβ & mTOR) that induces apoptosis in diffuse large B-cell lymphoma, follicular lymphoma, and B-ALL cell cultures (0.5-1 µM for 24h) by blocking constitutive PI3K pathway activation.

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库