SML4326

IKE

Name: IKE
Brand: SIGMA

≥97% (HPLC)

别名:

2-[[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]-4(3H)-quinazolinone, Imidazole ketone erastin

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关于此项目

经验公式（希尔记法）:

C₃₅H₃₅ClN₆O₅

化学文摘社编号:

1801530-11-9

分子量:

655.14

MDL number:

MFCD31813799

Assay:

≥97% (HPLC)

Form:

powder

Quality level:

100

主要文件

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assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Quality Level

100

Biochem/physiol Actions

IKE (Imidazole ketone erastin) is a highly potent and metabolically stable inhibitor of system xc– and inducer of ferroptosis. It appears that IKE inhibits cystine uptake leading to glutathione depletion. IKE inhibits tumor growth in mouse model of lymphoma.