生物来源
human
重组
expressed in E. coli
方案
≥97% (SDS-PAGE)
表单
lyophilized
分子量
~14.9 kDa
包装
pkg of 10 μg
杂质
<1.0 EU/μg endotoxin, tested
NCBI登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... IL32(9235)
一般描述
Human IL-32α is one of approximately 6 splice variants of a gene cloned from the human lung carcinoma stable transfectant, A549-Rβ. IL-32α has been shown to induce IL-8, TNF-α, and MIP-2 production from human and mouse macrophage cell lines. It is up-regulated in activated T- and NK-cells, and IFN-g-treated epithelial cells. Human recombinant IL-32α produced in E. coli is a 131 amino acid non-glycosylated polypeptide with a molecular mass of 14.9 kDa.
生化/生理作用
Interleukin-32 (IL-32) is a proinflammatory cytokine. It stimulates the generation of interleukin-6 and tumor necrosis factor-α. It also has a role in cell apoptosis and immune responses. IL32 has been associated with inflammatory diseases.
外形
Sterile Filtered white lyophilized (freeze-dried) powder.
制备说明
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/mL.
法规信息
新产品
此项目有
DNA methylation at IL32 in juvenile idiopathic arthritis.
Meyer B
Scientific Reports (2015)
Synthetic double-stranded RNA induces interleukin-32 in bronchial epithelial cells.
Ota K
Experimental Lung Research (2015)
Cytokines and microbicidal molecules regulated by IL-32 in THP-1-derived human macrophages infected with New World Leishmania species.
Dos Santos
PLoS Neglected Tropical Diseases (2017)
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