biological source
human
recombinant
expressed in E. coli
assay
≥97% (SDS-PAGE)
form
lyophilized
mol wt
~14.9 kDa
packaging
pkg of 10 μg
impurities
<1.0 EU/μg endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IL32(9235)
General description
Human IL-32α is one of approximately 6 splice variants of a gene cloned from the human lung carcinoma stable transfectant, A549-Rβ. IL-32α has been shown to induce IL-8, TNF-α, and MIP-2 production from human and mouse macrophage cell lines. It is up-regulated in activated T- and NK-cells, and IFN-g-treated epithelial cells. Human recombinant IL-32α produced in E. coli is a 131 amino acid non-glycosylated polypeptide with a molecular mass of 14.9 kDa.
Biochem/physiol Actions
Interleukin-32 (IL-32) is a proinflammatory cytokine. It stimulates the generation of interleukin-6 and tumor necrosis factor-α. It also has a role in cell apoptosis and immune responses. IL32 has been associated with inflammatory diseases.
Physical form
Sterile Filtered white lyophilized (freeze-dried) powder.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/mL.
法规信息
新产品
此项目有
Cytokines and microbicidal molecules regulated by IL-32 in THP-1-derived human macrophages infected with New World Leishmania species.
Dos Santos
PLoS Neglected Tropical Diseases (2017)
DNA methylation at IL32 in juvenile idiopathic arthritis.
Meyer B
Scientific Reports (2015)
Synthetic double-stranded RNA induces interleukin-32 in bronchial epithelial cells.
Ota K
Experimental Lung Research (2015)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持