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SRP4505

FABP5 human

Name: FABP5 human
Brand: SIGMA

recombinant, expressed in E. coli

别名:

E-FABP, Epidermal-type fatty acid-binding protein, Fatty acid-binding protein 5, Fatty acid-binding protein epidermal, Psoriasis-associated fatty acid-binding protein homolog

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关于此项目

NACRES:

NA.32

UNSPSC Code:

12352200

Form:

lyophilized

Assay:

≥98% (SDS-PAGE)

Biological source:

human

Recombinant:

expressed in E. coli

Mol wt:

~16 kDa

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属性

biological source

human

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE)

form

lyophilized

mol wt

~16 kDa

packaging

pkg of 100 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

NCBI accession no.

Q01469

UniProt accession no.

Q01469

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... FABP5(2171)

说明

General description

FABPs (fatty acid-binding proteins) are small 14-15kDa intracellular cytosolic proteins. They are needed for the transport of lipids to specific areas in cells. The FABP5 gene is mapped to human chromosome 8q21.

Biochem/physiol Actions

FABP5 (fatty acid-binding protein 5) is involved in the pathogenesis of metabolic diseases. Absence of FABP-4 and -5 in mice protects them against diet-induced obesity, insulin resistance, type 2 diabetes, atherosclerosis and fatty liver disease. FABP5 is also associated with bladder, pancreas, prostate, breast cancers and glioblastoma.

Physical form

Sterile filtered and Lyophilized without additives.

Preparation Note

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

5K244505

51105

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A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis.

Liu RZ, et al.

Genomics, 92, 436-436 (2008)

A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting.

Syamsunarno MR, et al.

PLoS ONE, 8, e79386-e79386 (2013)

Fatty acid activated PPARγ promotes tumorigenicity of prostate cancer cells by up regulating VEGF via PPAR responsive elements of the promoter.

Farzad S Forootan et al.

Oncotarget, 7(8), 9322-9339 (2016-01-28)

In previous work, it is suggested that the excessive amount of fatty acids transported by FABP5 may facilitate the malignant progression of prostate cancer cells through a FABP5-PPARγ-VEGF signal transduction axis to increase angiogenesis. To further functionally characterise the FABP5-PPARγ-VEGF

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全球贸易项目编号

货号	GTIN
SRP4505-100UG	04061837226687