SRP4561
Resistin from rat
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
别名:
ADSF, Adipose tissue-specific secretory factor, C/EBP-ε-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-α-like 2, Cysteine-rich secreted protein FIZZ3, RSTN
产品名称
Resistin from rat, recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
biological source
rat
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
form
lyophilized
mol wt
~11.9 kDa
packaging
pkg of 25 μg
impurities
endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
rat ... Retn(246250)
Application
Resistin from rat has been used to study the effect of resistin on gonadotropins and local ovarian hormone-induced steroidogenesis.
Biochem/physiol Actions
Resistin mediates energy homeostasis and inflammation process. Upregulation of resistin is observed in obesity. It is also known to increase blood glucose level and might promote insulin resistance. Thus, it might influence type 2 diabetes. Resistin might be linked to insulin resistance mediated myocardial infarction (MI). In rats, overexpression of resistin is observed in myocardial infarction and cardiac dysfunction.
General description
Resistin is a new member to of the family of adipocyte-secreted proteins. The biological functions of resistin, as well as its molecular target, are largely unknown. Whether it promotes or antagonizes insulin action is still unclear. Recombinant rat Resistin is an 11.9 kDa protein consisting of 94 amino acid residues and 16 additional amino acids residues-His Tag.
Resistin is an adipocytokine secreted by fat tissues and is localized to pancreatic α-cells in rat.
Resistin is an adipocytokine secreted by fat tissues and is localized to pancreatic α-cells in rat.
Physical form
Lyophilized from 20 mM Tris, pH 8.0.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Sitagliptin decreases ventricular arrhythmias by attenuated glucose-dependent insulinotropic polypeptide (GIP)-dependent resistin signaling in infarcted rats
Lee TM, et al.
Bioscience Reports, BSR20150139-BSR20150139 (2016)
Resistin aggravates the expression of proinflammatory cytokines in cerulein-stimulated AR42J pancreatic acinar cells
Jiang CY and Wang W
Molecular Medicine Reports, 15(1), 502-506 (2017)
Regulatory role of gonadotropins and local factors produced by ovarian follicles on in vitro resistin expression and action on porcine follicular steroidogenesis
Rak A, et al.
Biology of Reproduction, 92(6), 142-141 (2015)
Maha M Sabry et al.
Archives of physiology and biochemistry, 126(5), 389-398 (2019-01-08)
Obesity and atherosclerosis are inflammatory states involving variable metabolic signals. The adipokine resistin is implicated in adipose tissue dysfunction and is modulated by PPARγ. In this study, resistin and PPARγ role is investigated in the development of CVS disease. Forty-eight
JingJing Shang et al.
iScience, 26(7), 107025-107025 (2023-06-30)
Osteogenic differentiation (OD) of bone marrow mesenchymal stem cells (BMSCs) contributes significantly to the regeneration of bone defects. Resistin, an adipose tissue-specific secretory factor, has been shown to involve many different functions, including metabolism, inflammation, cancer, and bone remodeling. However
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