biological source
human
recombinant
expressed in E. coli
assay
≥98% (HPLC), ≥98% (SDS-PAGE)
form
lyophilized
mol wt
~27 kDa
packaging
pkg of 20 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... GDF7(151449)
General description
BMPs (bone morphogenetic proteins) belong to the transforming growth factor-β (TGF-β) superfamily of structurally related signaling proteins. BMP-12 is highly conserved across species. The gene encoding this protein is localized on human chromosome 2. Recombinant human BMP-12 is a 27kDa disulfide-linked homodimer containing two 122 amino acid polypeptide chains.
Application
Bone morphogenetic protein (BMP-12)/GDF-7 (growth differentiation factor 7) has been used as a supplement in human adipose stem cells (hASCs) growth media.
Biochem/physiol Actions
As implied by their name, BMPs (bone morphogenetic proteins) promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP-12 regulates chondrogenesis, bone morphogenesis, and neuron differentiation. It also has a role in seminal vesicle development.
Physical form
Sterile filtered and Lyophilized without additives.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute to a concentration of 0.1-1.0 mg/mL in water containing BSA (50 mg BSA per 1 mg of protein). This solution can then be diluted into other aqueous buffers.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Bone Morphogenetic Protein (BMP) signaling in development and human diseases.
Wang RN
Genes, 1(1), 87-105 (2014)
Bmp-12 activates tenogenic pathway in human adipose stem cells and affects their immunomodulatory and secretory properties.
Zarychta-Wisniewska W, et al.
BMC Cell Biology, 18(1), 13-13 (2017)
The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk.
Becker J
Cancer Medicine, 5(5), 888-891 (2016)
The family of bone morphogenetic proteins.
Ducy P and Karsenty G
Kidney International, 57(6), 2207-2214 (2000)
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