生物来源
human
重组
expressed in E. coli
方案
≥90% (SDS-PAGE)
表单
lyophilized
分子量
~24 kDa
包装
pkg of 20 μg
储存条件
avoid repeated freeze/thaw cycles
杂质
endotoxin, tested
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... FGF20(26281)
一般描述
The gene FGF20 (fibroblast growth factor 20) is mapped to human chromosome 8p22-p21.3. It is strongly expressed in the substantia nigra of the brain. It is also expressed during early embryonic development. FGF20 belongs to the FGF class of genes.
生化/生理作用
FGF20 (fibroblast growth factor 20) is a neurotrophin which plays an important role in growth and survival of neurons. It is mainly required for the survival of dopaminergic cells. It plays an important role in central nervous development and function. FGF20 interacts with the tyrosine kinase FGF receptor-1 (FGFR1). Mutation in FGF20 (rs12720208) is associated with the susceptibility of Parkinson′s disease. It is also a putative proto-oncogene. It is required for maintaining the Wnt/β-catenin pathway-mediated anchorage-independent cellular growth.
外形
Lyophilized from 20 mM Tris, pH 7.6, containing 1.5 M NaCl.
制备说明
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1 to 1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
法规信息
监管及禁止进口产品
Fibroblast growth factor 20 polymorphisms and haplotypes strongly influence risk of Parkinson disease.
van der Walt JM, et al.
American Journal of Human Genetics, 74, 1121-1121 (2004)
FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development.
Chamorro MN, et al.
The Embo Journal, 24, 73-73 (2005)
Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein.
Wang G, et al.
American Journal of Human Genetics, 82, 283-283 (2008)
Genetic variation in FGF20 modulates hippocampal biology.
Lemaitre H, et al.
The Journal of Neuroscience, 30, 5992-5992 (2010)
Gene-gene interaction between FGF20 and MAOB in Parkinson disease.
Gao X, et al.
Annals of Human Genetics, 72, 157-157 (2008)
商品
Fibroblast growth factors in cell culture and various growth factors for your research
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