产品名称
FGF-20 human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
biological source
human
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
lyophilized
mol wt
~24 kDa
packaging
pkg of 20 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... FGF20(26281)
Biochem/physiol Actions
FGF20 (fibroblast growth factor 20) is a neurotrophin which plays an important role in growth and survival of neurons. It is mainly required for the survival of dopaminergic cells. It plays an important role in central nervous development and function. FGF20 interacts with the tyrosine kinase FGF receptor-1 (FGFR1). Mutation in FGF20 (rs12720208) is associated with the susceptibility of Parkinson′s disease. It is also a putative proto-oncogene. It is required for maintaining the Wnt/β-catenin pathway-mediated anchorage-independent cellular growth.
General description
The gene FGF20 (fibroblast growth factor 20) is mapped to human chromosome 8p22-p21.3. It is strongly expressed in the substantia nigra of the brain. It is also expressed during early embryonic development. FGF20 belongs to the FGF class of genes.
Physical form
Lyophilized from 20 mM Tris, pH 7.6, containing 1.5 M NaCl.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1 to 1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
法规信息
监管及禁止进口产品
此项目有
Gene-gene interaction between FGF20 and MAOB in Parkinson disease.
Gao X, et al.
Annals of Human Genetics, 72, 157-157 (2008)
Genetic variation in FGF20 modulates hippocampal biology.
Lemaitre H, et al.
The Journal of Neuroscience, 30, 5992-5992 (2010)
Quantitative assessment of the effect of FGF20 rs12720208 variant on the risk of Parkinson's disease: a meta-analysis.
Wang X, et al.
Neurological Research, 39, 374-374 (2017)
FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development.
Chamorro MN, et al.
The Embo Journal, 24, 73-73 (2005)
Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein.
Wang G, et al.
American Journal of Human Genetics, 82, 283-283 (2008)
商品
Fibroblast growth factors in cell culture and various growth factors for your research
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