SRP4634
VEGF-C from mouse
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
别名:
VEGFC, Vascular Endothelial Growth Factor-C
biological source
mouse
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
lyophilized
potency
>200 ng/mL ED50
mol wt
~18.0 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Vegfc(22341)
General description
VEGF-C (vascular endothelial growth factor-C) is a member of the VEGF family of structurally related proteins. The gene encoding this protein is localized on mouse chromosome 8. The product here (VEGF-C from mouse) is a 129 amino acid recombinant protein that lacks the N-terminal and C-terminal extensions and contains only the middle third VEGF homology domain. Mouse VEGF-C exhibits about 85% homology with human and 97% homology with rat VEGF-C.
Biochem/physiol Actions
VEGF-C (vascular endothelial growth factor-C) has a role in lymphangiogenesis. It functions via the VEGF receptor-3 (VEGFR-3). Studies have shown that lymphatic endothelial cells do not form sprouting capillaries without VEGF-C. It has also been observed that this protein stimulates tumor lymphangiogenesis in xenotransplanted and transgenic mouse models of cancer.
Physical form
Lyophilized from acetic solution with 50 μg BSA per 1 μg VEGF-C.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/mL.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins.
Karkkainen MJ
Nature Immunology, 5(1), 74-80 (2004)
Overexpression of vascular endothelial growth factor C increases growth and alters the metastatic pattern of orthotopic PC-3 prostate tumors.
Tuomela J
BMC Cancer, 9, 362-362 (2009)
VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites.
Hirakawa S
Blood, 109(3), 1010-1017 (2007)
Induced lymphatic sinus hyperplasia in sentinel lymph nodes by VEGF-C as the earliest premetastatic indicator.
Lliersch R
International Journal of Oncology, 41(6), 2073-2078 (2012)
The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease.
Holmes DI and Zachary I
Genome Biology, 6(2), 209-209 (2005)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持