生物来源
human
重组
expressed in E. coli
方案
≥98% (SDS-PAGE)
表单
lyophilized
效能
0.5-5.0 μg/mL
分子量
~19.63 kDa
包装
pkg of 20 μg
储存条件
avoid repeated freeze/thaw cycles
杂质
endotoxin, tested
NCBI登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... VEGFB(7423)
一般描述
Vascular endothelial growth factor B (VEGF-B), a member of the VEGF family, is a potent growth and angiogenic cytokine. VEGF-B is expressed in all tissues except the liver. It forms cell surface-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a "cysteine knot" like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. The gene encoding this protein is localized on human chromosome 11q13 and contains seven exons. Recombinant human VEGF-B is a 38kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.
生化/生理作用
Vascular endothelial growth factor B (VEGF-B) promotes DNA synthesis in endothelial cells, regulates angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. It has a role in coronary vessel growth and cardiac hypertrophy, which might provide protection to heart against ischemic damage and heart failure. VEGF-B is also involved in neuroprotection. The protein might have a role in metabolic functions since it is highly expressed in tissues with highly active energy metabolism.
外形
Lyophilized without any additives.
制备说明
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/mL.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Roles of Vascular Endothelial Growth Factor in Amyotrophic Lateral Sclerosis
Ana Catarina
BioMed Research International, 947513-947513 (2014)
Vascular endothelial growth factor and angiogenesis.
Hoeben A et al
Pharmacological Reviews, 56(4), 549-580 (2004)
Vascular endothelial growth factor-B in physiology and disease.
Bry M et al
Physiological Reviews, 94(3), 779-794 (2014)
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