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Merck
CN

SRP4642

Sigma-Aldrich

VEGF-B human

recombinant, expressed in E. coli

别名:

VEGFB, Vascular Endothelial Growth Factor-B

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关于此项目

UNSPSC代码:
12352202
NACRES:
NA.32
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生物来源

human

重组

expressed in E. coli

方案

≥98% (SDS-PAGE)

表单

lyophilized

效能

0.5-5.0 μg/mL

分子量

~19.63 kDa

包装

pkg of 20 μg

储存条件

avoid repeated freeze/thaw cycles

杂质

endotoxin, tested

NCBI登记号

运输

wet ice

储存温度

−20°C

基因信息

human ... VEGFB(7423)

一般描述

Vascular endothelial growth factor B (VEGF-B), a member of the VEGF family, is a potent growth and angiogenic cytokine. VEGF-B is expressed in all tissues except the liver. It forms cell surface-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a "cysteine knot" like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. The gene encoding this protein is localized on human chromosome 11q13 and contains seven exons. Recombinant human VEGF-B is a 38kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.

生化/生理作用

Vascular endothelial growth factor B (VEGF-B) promotes DNA synthesis in endothelial cells, regulates angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. It has a role in coronary vessel growth and cardiac hypertrophy, which might provide protection to heart against ischemic damage and heart failure. VEGF-B is also involved in neuroprotection. The protein might have a role in metabolic functions since it is highly expressed in tissues with highly active energy metabolism.

外形

Lyophilized without any additives.

制备说明

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/mL.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Roles of Vascular Endothelial Growth Factor in Amyotrophic Lateral Sclerosis
Ana Catarina
BioMed Research International, 947513-947513 (2014)
Vascular endothelial growth factor and angiogenesis.
Hoeben A et al
Pharmacological Reviews, 56(4), 549-580 (2004)
Vascular endothelial growth factor-B in physiology and disease.
Bry M et al
Physiological Reviews, 94(3), 779-794 (2014)

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