SRP4823
MART-1 human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
别名:
Antigen LB39-AA, Antigen SK29-AA, Melanoma antigen recognized by T-cells 1, Protein Melan-A
biological source
human
recombinant
expressed in E. coli
assay
≥90% (HPLC), ≥90% (SDS-PAGE)
form
lyophilized
mol wt
~18.0 kDa
packaging
pkg of 5 μg
impurities
endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... MLANA(2315)
General description
Melanoma-associated antigen recognized by T cells-1 (MART-1) (also known as Melan-A) is a melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. It is a transmembrane protein which is hydrophobic in nature. Six other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, Tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. The protein is also expressed in melanoma tumors. Human MART-1 is purified by proprietary chromatographic techniques.
Biochem/physiol Actions
Melanoma-associated antigen recognized by T cells-1 (MART-1) has been shown to be essential for the functioning of glycoprotein-100 (gp100).
Physical form
Lyophilized without additives.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration 0.1-1 mg/mL. The solution can then be further diluted to other aqueous solutions.
法规信息
新产品
此项目有
Pierre L Triozzi et al.
Melanoma research, 25(6), 510-518 (2015-09-24)
Antigens that may be involved in the immune response to uveal melanoma have not been identified. Cellular and humoral responses to melanoma differentiation antigens, as well as to BRCA1-associated protein 1 (BAP1) and α-enolase, alterations of which are associated with
María Marcela Barrio et al.
PloS one, 7(7), e40311-e40311 (2012-07-07)
Dendritic cells (DC) can achieve cross-presentation of naturally-occurring tumor-associated antigens after phagocytosis and processing of dying tumor cells. They have been used in different clinical settings to vaccinate cancer patients. We have previously used gamma-irradiated MART-1 expressing melanoma cells as
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