SRP4826
p21-WAF-1 human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)
别名:
CDK-interacting protein 1, CDKN1A, Cyclin-dependent kinase inhibitor 1, MDA-6, Melanoma differentiation-associated protein 6, p21
biological source
human
recombinant
expressed in E. coli
assay
≥90% (HPLC), ≥90% (SDS-PAGE)
form
liquid
mol wt
~47 kDa
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... CDN1A(1026)
General description
p21/WAF1/Cip1/Sdi1/Pic1 is a tumor suppressor protein. Expression of p21WAF1 is induced by wild type, but not mutant, p53 suppressor protein. The p21/WAF1 protein binds to cyclin/CDK complexes and inhibits their kinase activity thereby stopping cell cycle progression. Meanwhile, the p21WAF1 protein also binds to PCNA (proliferating cell nuclear antigen) and blocks DNA replication but not the DNA repair process. Evidently, inactivation of p53 disrupts the p53-dependent expression of p21WAF1. p21WAF1 is a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recombinant P21/WAF1 is purified by proprietary chromatographic techniques.
Physical form
100 μg/ml in 50 mM Tris-Acetate, pH 7.5, 1 mM EDTA, and 20% Glycerol.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
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