SRP4826
p21-WAF-1 human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)
别名:
CDK-interacting protein 1, CDKN1A, Cyclin-dependent kinase inhibitor 1, MDA-6, Melanoma differentiation-associated protein 6, p21
生物来源
human
重组
expressed in E. coli
方案
≥90% (HPLC)
≥90% (SDS-PAGE)
表单
liquid
分子量
~47 kDa
储存条件
avoid repeated freeze/thaw cycles
杂质
endotoxin, tested
NCBI登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... CDN1A(1026)
一般描述
p21/WAF1/Cip1/Sdi1/Pic1 is a tumor suppressor protein. Expression of p21WAF1 is induced by wild type, but not mutant, p53 suppressor protein. The p21/WAF1 protein binds to cyclin/CDK complexes and inhibits their kinase activity thereby stopping cell cycle progression. Meanwhile, the p21WAF1 protein also binds to PCNA (proliferating cell nuclear antigen) and blocks DNA replication but not the DNA repair process. Evidently, inactivation of p53 disrupts the p53-dependent expression of p21WAF1. p21WAF1 is a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recombinant P21/WAF1 is purified by proprietary chromatographic techniques.
外形
100 μg/ml in 50 mM Tris-Acetate, pH 7.5, 1 mM EDTA, and 20% Glycerol.
制备说明
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
法规信息
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