SRP4928
脂质运载蛋白-2 人
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
别名:
MMP-9 的25 kDa α-2-微球蛋白相关亚单位, NGAL, p25, 中性粒细胞明胶酶相关脂质运载蛋白, 脂质运载蛋白-2, 致癌基因 24p3
产品名称
脂质运载蛋白-2 人, recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
biological source
human
recombinant
expressed in E. coli
assay
≥95% (HPLC)
≥95% (SDS-PAGE)
form
lyophilized
mol wt
~20 kDa
packaging
pkg of 50 μg
technique(s)
activity assay: suitable
impurities
endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... LCN2(3934)
Application
人LCN2（脂质运载蛋白2）已用于细胞增殖试验。它还用于肾癌细胞的电导免疫测定。
Biochem/physiol Actions
LCN2（脂质运载蛋白2）可能与肥胖及其相关的脂肪炎症有关。LCN2还参与细胞分化、肿瘤发生和细胞凋亡等多种过程。它是急性肾损伤、心血管疾病、狼疮肾炎和肠道炎症的早期标志物。LCN2在心力衰竭患者体内表达上调。它可以与MMP9（基质金属蛋白酶-9）结合并控制其稳定性。LCN2表达的变化与许多癌症有关，包括乳腺癌、结直肠癌、胰腺癌、卵巢癌、胃癌、甲状腺癌、卵巢癌、膀胱癌和肾癌。LCN2是一种多效性分子，在免疫反应、炎症、代谢稳态和感染等多种病理生理和生理活动中发挥作用。
General description
研究领域： 细胞信号传导。基因LCN2（脂质运载蛋白2）定位于人类染色体9q34。LCN2，一种分泌型糖蛋白，是一种脂肪因子。它在呼吸道和肠上皮细胞、内皮细胞、肾小管细胞以及心肌细胞等多种细胞中均有表达。LCN2属于脂质运载蛋白家族。LCN2由与疏水小分子结合的脂质结合结构域和与称为铁载体的细菌和哺乳动物蛋白结合的配体结合腔组成。
Physical form
不含添加剂的冻干品。
Preparation Note
打开样品瓶之前需离心。避免反复冻融。
用水复溶至浓度 0.1-1 mg/mL。然后将溶液进一步稀释至其他水溶液。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Vanessa Abella et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 20(8), 565-571 (2015-12-17)
Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a secreted glycoprotein that belongs to a group of transporters of small lipophilic molecules in circulation. LCN2 has been recently characterized as an adipose-derived cytokine. This adipokine is believed to
Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans.
Catalan V
Journal of Molecular Medicine, 87, 803-813 (2009)
Guoliang Wang et al.
International journal of biological sciences, 10(7), 798-806 (2014-08-01)
A key feature of pulmonary hypertension (PH) is the remodeling of small pulmonary arteries due to abnormal pulmonary artery smooth muscle cell (PASMC) proliferation and resistance to apoptosis. However, the cellular mechanisms underlying how PASMCs in the pathological condition of
Network based analyses of gene expression profile of LCN2 overexpression in esophageal squamous cell carcinoma.
Wu B
Scientific Reports, 4, doi: 10-doi: 10 (2014)
Plasma levels of neutrophil gelatinase-associated lipocalin in children with heart failure.
Tawfeek MS
Therapeutic Advances in Cardiovascular Disease, 10, 30-36 (2016)
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