SRP4964
VEGF121 murine
recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)
别名:
Vegf, Vegf120, Vegf164, Vegf188, Vegfa, Vpf
biological source
rat
recombinant
expressed in E. coli
assay
≥97% (HPLC), ≥97% (SDS-PAGE)
form
lyophilized
potency
1-5 ng/mL
mol wt
~28.2 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... VEGFA(7422)
General description
Vascular endothelial growth factor 121 (VEGF121) belongs to the platelet-derived growth factor (PDGF)/VEGF family characterized by the presence of eight conserved cysteine residues and a cystine knot structure. VEGF121 is a disulfide-linked homodimer containing 121 amino acids and is the only variant of VEGF that does not interact with heparin.
Recombinant Mouse VEGF-121 is a truncated version of Mouse VEGF-165.
Recombinant Mouse VEGF-121 is a truncated version of Mouse VEGF-165.
Biochem/physiol Actions
VEGF121/rGel (toxin gelonin) fusion plays a vital role in targeted destruction of tumor vasculature in vivo and it can be used as a potent anti-cancer agent in cancer treatment. In mice, overexpression of VEGF121 enhanced the tumor growth, whereas VEGF165 decreased tumor growth, without affecting cancer cell proliferation in culture.
Physical form
Lyophilized with no additives.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute the lyophilized product with sterile water at a concentration of 0.1 – 0.5 mg/mL, which can be further diluted into other aqueous solutions.
法规信息
新产品
此项目有
The splice variants of vascular endothelial growth factor (VEGF) and their receptors.
Robinson CJ and Stringer SE.
Journal of Cell Science, 114(pt5), 853-865 (2001)
In vitro and in vivo studies of a VEGF121/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors.
Veenendaal LM
Proceedings of the National Academy of Sciences of the USA, 99(12), 7866-7871 (2002)
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