SRP4964
VEGF121 murine
recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)
别名:
Vegf, Vegf120, Vegf164, Vegf188, Vegfa, Vpf
生物来源
rat
重组
expressed in E. coli
方案
≥97% (HPLC)
≥97% (SDS-PAGE)
表单
lyophilized
效能
1-5 ng/mL
分子量
~28.2 kDa
包装
pkg of 10 μg
储存条件
avoid repeated freeze/thaw cycles
杂质
endotoxin, tested
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... VEGFA(7422)
一般描述
Vascular endothelial growth factor 121 (VEGF121) belongs to the platelet-derived growth factor (PDGF)/VEGF family characterized by the presence of eight conserved cysteine residues and a cystine knot structure. VEGF121 is a disulfide-linked homodimer containing 121 amino acids and is the only variant of VEGF that does not interact with heparin.
Recombinant Mouse VEGF-121 is a truncated version of Mouse VEGF-165.
Recombinant Mouse VEGF-121 is a truncated version of Mouse VEGF-165.
生化/生理作用
VEGF121/rGel (toxin gelonin) fusion plays a vital role in targeted destruction of tumor vasculature in vivo and it can be used as a potent anti-cancer agent in cancer treatment. In mice, overexpression of VEGF121 enhanced the tumor growth, whereas VEGF165 decreased tumor growth, without affecting cancer cell proliferation in culture.
外形
Lyophilized with no additives.
制备说明
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute the lyophilized product with sterile water at a concentration of 0.1 – 0.5 mg/mL, which can be further diluted into other aqueous solutions.
法规信息
新产品
此项目有
The splice variants of vascular endothelial growth factor (VEGF) and their receptors.
Robinson CJ and Stringer SE.
Journal of Cell Science, 114(pt5), 853-865 (2001)
In vitro and in vivo studies of a VEGF121/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors.
Veenendaal LM
Proceedings of the National Academy of Sciences of the USA, 99(12), 7866-7871 (2002)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持