SRP5216
TTBK2 (70-538), active, GST tagged from mouse
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
别名:
TTBK, TTBK1, TTK, mKIAA0847
recombinant
expressed in baculovirus infected Sf9 cells
product line
PRECISIO® Kinase
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
315-426 nmol/min·mg
mol wt
~88 kDa
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
mouse ... Ttbk2(140810)
General description
TTBK2 or tau tubulin kinase 2 is a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. TTBK2 is a member of the casein kinase (CK1) group of eukaryotic protein kinases that is involved in tau phosphorylation and aggregation. Mutations in TTBK2 cause spinocerebellar ataxia type 11 (SCA11) (a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem).
Physical form
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Preparation Note
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
10 - Combustible liquids
wgk
WGK 1
法规信息
新产品
此项目有
Shinji Sato et al.
Journal of neurochemistry, 98(5), 1573-1584 (2006-08-23)
Neurofibrillary tangles, which are major pathological hallmarks of Alzheimer's disease (AD), are composed of paired helical filaments (PHFs) containing hyperphosphorylated tau. Specific kinases regulate tau phosphorylation and are closely linked to the pathogenesis of AD. We have characterized a human
Henry Houlden et al.
Nature genetics, 39(12), 1434-1436 (2007-11-27)
The microtubule-associated protein tau (encoded by MAPT) and several tau kinases have been implicated in neurodegeneration, but only MAPT has a proven role in disease. We identified mutations in the gene encoding tau tubulin kinase 2 (TTBK2) as the cause
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