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SRP5225

PAD3, GST tagged human

Name: PAD3, GST tagged human
Brand: SIGMA

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

别名:

MGC126307, MGC126308, PADI3, PDI3

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关于此项目

NACRES:

NA.32

UNSPSC Code:

12352200

Form:

buffered aqueous glycerol solution

Assay:

≥70% (SDS-PAGE)

Biological source:

human

Recombinant:

expressed in baculovirus infected Sf9 cells

Mol wt:

~97 kDa

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属性

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

~97 kDa

NCBI accession no.

NM_016233

application(s)

cell analysis

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PADI3(51702)

说明

General description

Peptidyl arginine deiminase 3 (PAD3) is a member of the peptidyl arginine deiminase family of enzymes. It is expressed in the epithelium and hair follicles. The gene encoding this protein is localized on human chromosome 1p36.13.

Biochem/physiol Actions

Peptidyl arginine deiminases catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. PAD3 modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. It converts arginine to citrulline in filaggrin at a faster rate than it does in trichohyalin. Together with the type I enzyme (PAD1), PAD3 play a role in terminal differentiation of the epidermis.

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Analysis Note

This protein is not assayed for enzymatic activity.

存储类别

10 - Combustible liquids

wgk

WGK 1

法规信息

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分析证书(COA)

Lot/Batch Number

I255-2

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Potential Role of Peptidylarginine Deiminase Enzymes and Protein Citrullination in Cancer Pathogenesis

Sunish Mohanan

Biochemistry Research International (2012)

Acefylline activates filaggrin deimination by peptidylarginine deiminases in the upper epidermis.

Mechin MC

Journal of Dermatological Science (2016)

Human peptidylarginine deiminase type III: molecular cloning and nucleotide sequence of the cDNA, properties of the recombinant enzyme, and immunohistochemical localization in human skin.

T Kanno et al.

The Journal of investigative dermatology, 115(5), 813-823 (2000-11-09)

Peptidylarginine deiminase catalyzes the post-translational modification of proteins through the conversion of arginine to citrulline in the presence of calcium ions. In rodents, peptidylarginine deiminase has been classified into four isoforms, types I, II, III, and IV, which are distinct

全球贸易项目编号

货号	GTIN
SRP5225-20UG	04061832943145