SRP6051
RAGE human
recombinant, expressed in human cells, ≥95% (SDS-PAGE), ≥95% (HPLC)
别名:
HDNF, NGF-2, NT-3, Neurotrophin-3, Receptor for advanced glycosylation end products
一般描述
Advanced glycosylation end product-specific receptor, also known as receptor for advanced glycosylation end products, AGER and RAGE, belongs to the immunoglobulin superfamily of cell surface molecules. It lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Besides AGEs, AGER is also able to bind other ligands which is thought to result in pro-inflammatory gene activation. It is known that AGER serves as a mediator of both acute and chronic vascular inflammation in certain conditions such as atherosclerosis and in particular as a complication of diabetes. Furthermore, it plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.
外形
Lyophilized from a 0.2 μm filtered solution of 20 mM PB and 150 mM NaCl, pH7.2.
制备说明
Centrifuge the vial prior to opening.
Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 μg/mL.). After adding 1x PBS, let the tube stand at room temperature for 3 minutes to allow lyophilized protein to dissolve. Mix the solution by inverting the tube 5 times. Centrifuge to pool sample.
其他说明
Recombinant human AGER/RAGE produced by transfected human cell is a secreted protein with sequence (Ala23-Ala344) of human AGER/RAGE (Uniprot Entry: Q15109) fused with a poly-histidine tag at the C-terminus.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
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A Deguchi et al.
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