生物来源
human
重组
expressed in E. coli
方案
≥95% (SDS-PAGE)
表单
liquid
分子量
21.2 kDa
包装
pkg of 100 μg
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... PPIB(5479)
一般描述
Cyclophilin B belongs to the cyclophilin family of immunophilins. It is present in the cytoplasm, nucleus, endoplasmic reticulum (ER)/golgi and plasma membrane. The protein can also be secreted from cells. The associated gene is mapped to human chromosome 15q22.
生化/生理作用
In endoplasmic reticulum (ER), Cyclophilin B works as a chaperone for exported proteins. It also participates in the intracellular transport of collagen and proper formation of collagen fibril. Cyclophilin B can bind to the Gag protein of human immunodeficiency type 1 (HIV-1) and helps in HIV replication. It is also involved in the infection of hepatitis C virus (HCV), Japanese encephalitis virus (JEV) and human papillomavirus type 16 (HPV16). Cyclophilin B protects against ER-mediated hypoxia-induced cell death. It is overexpressed in various malignancies.
外形
1 mg/mL solution in 20 mM Tris-HCl buffer (pH 8.0) containing 20 mM NaCl, 0.5 mM DTT, 10% glycerol.
制备说明
Centrifuge the vial prior to opening.
其他说明
MLLPGPSAAD EKKKGPKVTV KVYFDLRIGD EDVGRVIFGL FGKTVPKTVD NFVALATGEK GFGYKNSKFH RVIKDFMIQG GDFTRGDGTG GKSIYGERFP DENFKLKHYG PGWVSMANAG KDTNGSQFFI TTVKTAWLDG KHVVFGKVLE GMEVVRKVES TKTDSRDKPL KDVIIADCGK IEVEKPFAIA KE
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
What is new in genetics and osteogenesis imperfecta classification?
Valadares ER, et al.
Jornal de Pediatria, 90, 536-536 (2014)
Cyclophilin B supports Myc and mutant p53-dependent survival of glioblastoma multiforme cells.
Choi JW, et al.
Cancer Research, 74, 484-484 (2014)
Cyclophilin B is involved in p300-mediated degradation of CHOP in tumor cell adaptation to hypoxia.
Jeong K, et al.
Cell Death and Differentiation, 21, 438-438 (2014)
Jason DeBoer et al.
Virology, 489, 282-291 (2016-01-18)
Cyclophilin B (CypB) is a member of the immunophilin family and intracellular chaperone. It predominantly localizes to the ER, but also contains a nuclear localization signal and is secreted from cells. CypB has been shown to interact with the Gag
Wei Zhang et al.
The Journal of clinical investigation, 131(20) (2021-09-03)
Atrial natriuretic peptide (ANP) is an important hormone in cardiovascular biology. It is activated by the protease corin. In pregnancy, ANP and corin promote uterine spiral artery remodeling, but the underlying mechanism remains unknown. Here we report an ANP function
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