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SRP6067

Cyclophilin D human

Name: Cyclophilin D human
Brand: SIGMA

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

别名:

CYP-40, CYPD, PPID, Peptidyl prolyl isomerase D

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关于此项目

NACRES:

NA.32

UNSPSC Code:

12352200

Form:

liquid

Assay:

≥95% (SDS-PAGE)

Biological source:

human

Recombinant:

expressed in E. coli

Mol wt:

42.9 kDa

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属性

biological source

human

recombinant

expressed in E. coli

assay

≥95% (SDS-PAGE)

form

liquid

mol wt

42.9 kDa

packaging

pkg of 100 μg

NCBI accession no.

Q08752

UniProt accession no.

Q08752

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PPID(5481)

说明

General description

Cyclophilin D is a member of peptidyl-propyl cis-trans isomerase (PPIase) family. It is a mitochondrial matrix protein and a component of the mitochondrial permeability transition pore (MPTP).

Application

Human cyclophilin D has been used to study the effects of muscle denervation on the opening of the permeability transition pore and on the expression of cyclophilin D in rats.

Biochem/physiol Actions

Cyclophilin D catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerates the folding of proteins and thus their formation. It plays a decisive role in mitochondrial permeability transition. The protein can bind to the immunosuppressant cyclosporine A and its overexpression suppresses the apoptosis in cancer cells.

Physical form

1 mg/mL solution in PBS (pH 7.4) containing 10% glycerol.

Preparation Note

Centrifuge the vial prior to opening.

Other Notes

MGSSHHHHHH SSGLVPRGSH MSHPSPQAKP SNPSNPRVFF DVDIGGERVG RIVLELFADI VPKTAENFRA LCTGEKGIGH TTGKPLHFKG CPFHRIIKKF MIQGGDFSNQ NGTGGESIYG EKFEDENFHY KHDREGLLSM ANAGRNTNGS QFFITTVPTP HLDGKHVVFG QVIKGIGVAR ILENVEVKGE KPAKLCVIAE CGELKEGDDG GIFPKDGSGD SHPDFPEDAD IDLKDVDKIL LITEDLKNIG NTFFKSQNWE MAIKKYAEVL

存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Muscle denervation promotes opening of the permeability transition pore and increases the expression of cyclophilin D

Kristina Csukly

The Journal of Physiology (2006)

Formation of High-Conductive C Subunit Channels upon Interaction with Cyclophilin D.

Giuseppe Federico Amodeo et al.

International journal of molecular sciences, 22(20) (2021-10-24)

The c subunit of the ATP synthase is an inner mitochondrial membrane (IMM) protein. Besides its role as the main component of the rotor of the ATP synthase, c subunit from mammalian mitochondria exhibits ion channel activity. In particular, c

Influence of cyclophilin D protein expression level on endothelial cell oxidative damage resistance.

Peng JZ

Genetics and molecular research : GMR, 14(2), 4258-4268 (2015)

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全球贸易项目编号

货号	GTIN
SRP6067-100UG	04061837242908