生物来源
human
重组
expressed in E. coli
方案
≥95% (SDS-PAGE)
表单
liquid
分子量
59.5 kDa (533 aa, 1-494 aa + NT His-Tag)
包装
pkg of 50 μg
NCBI登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... UGDH(7358)
一般描述
UDP-glucose 6-dehydrogenase (UGDH) is encoded by the gene mapped to human chromosome 4p14. UGDH is part of the UDP-glucose/GDP-mannose dehydrogenase family and is a widely expressed enzyme localized in the liver.
生化/生理作用
UDP-glucose 6-dehydrogenase (UGDH) transfers UDP-glucose to UDP-glucuronate and thus takes part in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. UGDH is implicated in various cellular processes such as, detoxification, polysaccharide biosynthesis and embryonic development.
外形
0.5 mg/mL solution in 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 1 mM DTT, 0.1 M NaCl, and 1 mM EDTA.
制备说明
Centrifuge the vial prior to opening.
其他说明
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSELEM FEIKKICCIG AGYVGGPTCS VIAHMCPEIR VTVVDVNESR INAWNSPTLP IYEPGLKEVV ESCRGKNLFF STNIDDAIKE ADLVFISVNT PTKTYGMGKG RAADLKYIEA CARRIVQNSN GYKIVTEKST VPVRAAESIR RIFDANTKPN LNLQVLSNPE FLAEGTAIKD LKNPDRVLIG GDETPEGQRA VQALCAVYEH WVPREKILTT NTWSSELSKL AANAFLAQRI SSINSISALC EATGADVEEV ATAIGMDQRI GNKFLKASVG FGGSCFQKDV LNLVYLCEAL NLPEVARYWQ QVIDMNDYQR RRFASRIIDS LFNTVTDKKI AILGFAFKKD TGDTRESSSI YISKYLMDEG AHLHIYDPKV PREQIVVDLS HPGVSEDDQV SRLVTISKDP YEACDGAHAV VICTEWDMFK ELDYERIHKK MLKPAFIFDG RRVLDGLHNE LQTIGFQIET IGKKVSSKRI PYAPSGEIPK FSLQDPPNKK PKV
储存分类代码
11 - Combustible Solids
WGK
WGK 1
法规信息
常规特殊物品
此项目有
Ping Cai et al.
Bioscience, biotechnology, and biochemistry, 79(7), 1090-1093 (2015-03-15)
An NADPH-dependent sorbose reductase from Candida albicans was identified to catalyze the asymmetric reduction of ethyl 4-chloro-3-oxobutanoate (COBE). The activity of the recombinant enzyme toward COBE was 6.2 U/mg. The asymmetric reduction of COBE was performed with two coexisting recombinant
Assignment1 of the UGDH locus encoding UDP-glucose dehydrogenase to human chromosome band 4p15. 1 by radiation hybrid mapping.
Marcu O, et al.
Cytogenetic and genome research, 86(3-4), 244-245 (1999)
cDNA cloning and expression analysis of the human UDPglucose dehydrogenase.
Peng H L, et al.
Proceedings of the National Science Council, Republic of China. Part B, Life Sciences, 22(4), 166-172 (1998)
UDP-glucose dehydrogenase activity and optimal downstream cellular function require dynamic reorganization at the dimer-dimer subunit interfaces.
Hyde A S, et al.
The Journal of Biological Chemistry, M113-M113 (2013)
Prognostic significance of genetic alterations detected by high-density single nucleotide polymorphism array in gastric cancer.
Tada M, et al.
Cancer Science, 101(5), 1261-1269 (2010)
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