SRP6160
FGF-4 human
recombinant, expressed in human cells, ≥95% (SDS-PAGE)
别名:
Fibroblast growth factor 4, HBGF4, Heparin-binding growth factor 4, K-fibroblast growth factor, KFGF
biological source
human
recombinant
expressed in human cells
assay
≥95% (SDS-PAGE)
form
lyophilized
mol wt
(17 and 27 kDa, monomer, glycosylated)
packaging
pkg of 10 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... FGF4(2249)
General description
The FGF4 (fibroblast growth factor 4) gene is mapped to human chromosome 11q13.3. It is expressed during early embryonic development. In adults, it is strongly expressed in the testis.
Biochem/physiol Actions
FGF4 (fibroblast growth factor 4) helps in preserving the self-renewal capability of normal stem cells. The encoded protein has the ability to interact with FGFR1c (FGF receptor 1c) and FGFR2c. It also binds to FGFR3c and FGFR4, but to a lesser extent. FGFR4 is also required for cellular differentiation, morphogenesis and proliferation. It modulates proliferation and differentiation of normal stem cells, progenitor cells and cancer cells.
Physical form
Lyophilized from a PBS solution.
Preparation Note
Centrifuge the vial prior to opening.
Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.
Yasuda K, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 94(12), 1355-1355 (2014)
Eryn Wicklow et al.
PLoS genetics, 10(10), e1004618-e1004618 (2014-10-24)
Pluripotent epiblast (EPI) cells, present in the inner cell mass (ICM) of the mouse blastocyst, are progenitors of both embryonic stem (ES) cells and the fetus. Discovering how pluripotency genes regulate cell fate decisions in the blastocyst provides a valuable
Martina Johannesson et al.
PloS one, 4(3), e4794-e4794 (2009-03-12)
Retinoic acid (RA) and fibroblast growth factor 4 (FGF4) signaling control endoderm patterning and pancreas induction/expansion. Based on these findings, RA and FGFs, excluding FGF4, have frequently been used in differentiation protocols to direct differentiation of hESCs into endodermal and
Increased FGF3 and FGF4 gene dosage is a risk factor for craniosynostosis.
Grillo L, et al.
Gene, 534(2), 435-439 (2014)
Evgeniya A Vaskova et al.
PloS one, 9(2), e88256-e88256 (2014-02-08)
In rodent female mammals, there are two forms of X-inactivation - imprinted and random which take place in extraembryonic and embryonic tissues, respectively. The inactive X-chromosome during random X-inactivation was shown to contain two types of facultative heterochromatin that alternate
商品
Fibroblast growth factors in cell culture and various growth factors for your research
Role of growth factors in stem cell differentiation and various growth factors for your research at sigmaaldrich.com
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