SRP6169
IL-1β 人
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
别名:
Catabolin, 内源性热原（EP）, 单核细胞因子（MCF）, 淋巴细胞激活因子（LAF）, 白细胞内源介质（LEM）
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关于此项目
Form:
lyophilized
Assay:
≥95% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in HEK 293 cells
Mol wt:
(18 and 25 kDa, monomer, glycosylated)
biological source
human
recombinant
expressed in HEK 293 cells
assay
≥95% (SDS-PAGE)
form
lyophilized
mol wt
(18 and 25 kDa, monomer, glycosylated)
packaging
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... IL1B(3553)
General description
白细胞介素-1β（IL1B）由活化的巨噬细胞产生。它被合成为pro-IL-1β，其在促炎蛋白酶半胱天冬酶-1的帮助下变为活性形式的IL-1β。IL-1β属于IL-1基因家族。它是一种促炎性细胞因子。该基因定位于人类染色体 2q14。与大肠埃希菌表达的蛋白质相比，IL-1β在促进人CD4+T细胞分化为Th17（T辅助）细胞方面的效力高50%。该细胞因子在无血清、化学成分明确的培养基中产生。
Application
- IL-1β（IL1B）已用于检查促炎细胞因子刺激后上皮细胞中NGAL（中性粒细胞明胶酶相关脂质运载蛋白）的表达。
- 它已用于检查人软骨细胞中N-乙酰氨基葡萄糖的抗炎活性。
- 它已被用于在人冠状动脉内皮细胞中产生炎性内皮。
Biochem/physiol Actions
IL-1β（IL1B）通过诱导IL-2释放，B细胞成熟和增殖以及成纤维细胞生长因子活性来刺激胸腺细胞增殖。IL-1β蛋白参与炎症反应，被确定为内源性致热原，据报道可刺激滑膜细胞释放前列腺素和胶原酶。IL-1β存在于慢性发炎组织中，也存在于纤维发生的组织中。它将中性粒细胞和巨噬细胞带到感染部位。IL-1β基因突变与过敏性紫癜的肾脏表现和肾脏后遗症有关。它还与1型糖尿病中β细胞的破坏有关。
Physical form
从PBS溶液中冻干。
Preparation Note
打开样品瓶之前需离心。
用含0.1%无内毒素重组人血清白蛋白的无菌PBS复溶。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
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