生物来源
human
重组
expressed in E. coli
方案
≥95% (SDS-PAGE)
表单
liquid
分子量
35.9 kDa
包装
pkg of 1 mg
pkg of 50 μg
浓度
1 mg/mL
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... CATK(1513)
一般描述
Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). Cathepsin K is synthesized as an inactive proenzyme (35.1 kDa) that is converted to its mature active form (23.6 kDa) by proteolytic cleavage of its 99-amino-acid propeptide domain. The in-vitro processing of procathepsin K to mature cathepsin K is autocatalytic.
外形
1 mg/mL solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0).
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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