biological source
human
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
form
lyophilized powder
mol wt
~13 kDa
packaging
pkg of 10 μg
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... FNDC5(252995)
General description
鸢尾素是最近鉴定的由小鼠和人类骨骼肌分泌的运动诱导激素。鸢尾素是从I型膜蛋白FNDC5（纤连蛋白 III 型域包含蛋白 5）上切割出来的。 FNDC5主要表达于肌肉中。肾、肝和肺中也含有低水平的mRNA。 FNDC5基因位于人染色体1p35.1上。
Biochem/physiol Actions
鸢尾素（Irisin）能够激活米色脂肪细胞（米色细胞的基因表达模式与白色或棕色脂肪不同，并且对多肽激素鸢尾素更敏感），并通过增加能量消耗来改善全身代谢。它主要负责将白色脂肪转化为棕色脂肪。这种转化增强了代谢解偶联和热量消耗。 鸢尾素始终与运动对细胞代谢的有益反应有关。在肥胖和2型糖尿病患者中，低水平的循环鸢尾素是脂肪组织和肌肉的特征。
Physical form
从PBS中冻干。
Preparation Note
使用100μL 无菌水重悬至 0.1 mg/mL。
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Rujun Zeng et al.
Bioscience trends, 12(6), 580-586 (2019-01-25)
Irisin is a myokine secreted from the cleavage of fibronectin type III domain-containing protein 5 (FNDC5) and has an effect on bone formation. There are limited studies about the structure of irisin and its functional unit. In order to clarify
Elke Albrecht et al.
Molecular metabolism, 34, 124-135 (2020-03-18)
Considerable uncertainty remains regarding the veracity of measuring myokine irisin more than seven years after its original description. Unresolved issues include the nature of transcription of the irisin precursor fibronectin type III domain containing 5 (FNDC5) gene across species, the
Is irisin a human exercise gene?
Timmons JA
Nature, 488, E9-10 (2012)
Gianluca Vadalà et al.
Cells, 9(6) (2020-06-21)
Physical exercise favors weight loss and ameliorates articular pain and function in patients suffering from osteoarthritis. Irisin, a myokine released upon muscle contraction, has demonstrated to yield anabolic effects on different cell types. This study aimed to investigate the effect
Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity.
Staiger H, et al.
PLoS ONE, 8, e61903-e61903 (2013)
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